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After reading the methods section from the abstract, determine what type of study design was used write down a strength and limitation of the study_design Possible answers include case control study, cohort study, ecological study, cross sectional study, and experimental study. 24) METHODS/DESIGN: This is a phase 2 dose escalation study of lisdexamfetamine for the treatment of methamphetamine dependence. Twenty individuals seeking treatment for methamphetamine dependence will be recruited at two Australian drug and alcohol services. All participants will undergo a si regime of 100 to 250 mg lisdexamfetamine, dispensed daily on site, over an 8-week period. Participants will be offered counselling as standard care. For the primary objectives, the outcome variables will be adverse events monitoring, drug tolerability and regimen completion ngle-blinded ascending-descending dose Type of Study: Strengths: Limitation:11:38 PM Sat Dec 1 30% 10. s3.us-east-1.amazonaws.com Limitation 25) METHODS: Twenty college students were physician diagnosed with a concussion and compared to 20 non-concussed controls matched on age, sex, physical activity, and sleep quality. A wrist-worn ActiGraph GT9X Link was provided during initial evaluatiorn (within 72 hours post-injury for concussed) and worn continuously until symptom resolution (duration matched for non-concussed). All participants completed a sleep symptom severity checklist, the Pittsburgh Sleep Quality Index (PSQI), and the Epworth Sleepiness Scale (ESS) RESULTS: At 2-3 days post-injury, concussed individuals took longer to fall asleep compared to controls (p-0.002). Poorer sleep quality (p<0.001), excessive daytime sleepiness (p-0.014), and worse sleep symptoms (p<0.001) existed in concussed compared to controls Type of Study: Strength Limitation 26) METHODS: Flame retardants are commonly used in consumer products found in U.S. households. Despite the widespread presence of these compounds in home environments, and their structural similarity to neurotoxic OP pesticides, understanding of human exposure and health effects of PFRs is limited. We measured four urinary PFR metabolites from pregnant women in the CHAMAcoS study (n-310) and assessed neurodevelopment of their children at age 7. We observed decreases of 2.9 points (95% Confidence Interval (CI):-6.3, 0.5) and 3.9 points (95% CI: -7.3,-0.5) in Full-Scale intelligence quotient and Working Memory, respectively, for each ten-fold increase in DPHP in adjusted regression models (n-248)

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23, type of study: experimental study

Strength: Twenty individual undergo a single blinded ascending,descending dose regimen of 100 to 250mg lisdexamfetamine for 8weeks .

Limitation: lisdexamfetamine for the treatment of methamphetamine dependence..

24, Type of study: cross sectional study

Strength: participants completed a sleep symptom severity checklist, the Pitts burgh sleep quality Intex(PSQI), and the Elworth sleepiness scale (ESS)

Limitation: A wrist worn actigraph GT9X link was provided during initial evaluation ( within 72hours post-injury for concussed) and worn continuously until symptom resolution..

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