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What is required for the following reaction? CO2 # # O an active site lysine residue thiamine pyrophosphate as a coenzyme a S
by causing the phosphorylation of Glucagon activates glycolysis. a regulatory enzyme of gluconeogenesis; hexokinase O glucone
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Answer #1

1. What is required for the following reaction?

CO2 Coo 1H

ans) NAD+ as an oxidising agent.

Here the reaction is the oxidation of the Pyruvic Acid. Primary alternation of the Pyruvic acid in the transition reaction is done by the elimination of one carbon and two oxygen atoms in the form of carbon di oxide. In this process NAD+ is used as the oxidising agent. During the removal of carbondi oxide, by giving up the energy, NAD+ is transformed into its higher energy as NADH..

2. Glucagon activates gluconeogensis; pyruvate kinase by causing the phosphorylation of glycolysis; pyruvate kinase, a regulatory enzyme of glycolysis

Explanation : Activation of gluconeogenesis by glucagon is carried out in the way of diminishing the disposal rate of phopshoenolpyruvate by pyruvate kinase.Through cyclic AMP(cAMP) and protein kinase which depends on the cAMP, Glucagon strengthen the phosphorylation of pyruvate kinase, phosphofructokinase and fructose-1,6-biphosphatase. Glucose synthesis enhancement, decreased recycling of phosphoenolpyruvate to pyruvate and enzyme inhibition are the effects of Phosphorylation of pyruvate kinase.

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