Question

please help with my ochem extra credit!

Extra Credit Assignment Glioblastoma multiforme (GBM) is a highly lethal brain cancer. Uncontrolled proliferation of glial cells in neural tissue is the primary cause of GBM, and this activity has been attributed to the glial cell membrane protein vascular endothelial growth factor receptor (VEFGR). This protein is a high-affinity tyrosine kinase receptor for growth factor ligands. A genetic mutation causes overexpression of this protein. This overexpression may cause increased glial cell response to growth factors which then triggers rapid cancer cell proliferation Your research team has determined that VEFGR may be a suitable target for cancer therapy. You have tested a compound, compound B, which shows potential as an irreversible inhibitor of VEFGR. Your only problem is figuring out how to synthesize compound B. You have determined that compound A is the most cost-effective starting reactant to used to synthesize compound B. Propose a three-step synthesis (or more) to convert compound A to compound B using any reagents. You can use any of the reagents as few or many times as you like, as long as you develop a reasonable synthesis of compound B. Compound A Compound B You do not have to draw the mechanism for each step, but you must show what reagent(s) you used for a particular reaction and what the product would be. Ignore all potential side-products. Please write a sentence or two about this activity, was it useful or helpful to you? too challenging or too easy? Any comments will be appreciated.

Answer 1

DBU or tBu OK t Budh 103/Meas oko nolysis cho oy eno u jм 1st қор не са си Вka ka to remove the Proton for less hindered site followed by allimination reactia to give alkene which on further Loronolysis with oz/ Mess to give Procluet B.