Table 5.4 presents some of the many known mutations in the genes encoding theα- andβ-globin subunits of hemoglobin.
a. Some of these mutations affect subunit interactions between the subunits. In an examination of the tertiary structure of globin chains, where would you expect to find amino acid changes in mutant globins that affect formation of the hemoglobinα2β2 quaternary structure?
b. Other mutations, such as the S form of theβ-globin chain, increase the tendency of hemoglobin tetramers to polymerize into very large structures. Where might you expect the amino acid substitutions to be in these mutants?
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