Drug content assessment. Refer to Exercise 4.108 (p. 208) and the Analytical Chemistry (De...

Drug content assessment. Refer to Exercise 4.108 (p. 208) and the Analytical Chemistry (Dec. 15, 2009) study in which scientists used high-performance liquid chromatography to determine the amount of drug in a tablet. Twenty-five tablets were produced at each of two different, independent

sites. Drug concentrations (measured as a percentage) for the tablets produced at the two sites are listed in the accompanying table and saved in the DRUGCON file. The scientists want to know whether there is any difference between the mean drug concentration in tablets produced at Site 1 and the corresponding mean at Site 2. Use the MINITAB printout (bottom of page) to help the scientists draw a conclusion.

Based on Borman, P. J., Marion, J. C., Damjanov, I., and Jackson, P. “Design and analysis of method equivalence studies.” Analytical Chemistry , Vol. 81, No. 24, December 15, 2009.