comparison of pernicious anemia and sickle cell anemia.
Sickle cell anemia is an inherited (Genetic)disease that is characterized by the destruction of Red blood cells. It is otherwise known as hemolytic anemia because of the destruction of RBCs.
In sickle cell anemia, there is hemoglobin protein is abnormal which resulted in difficulty inflow of RBCs in circulation, especially in small blood vessels.
Pernicious anemia is a nutrition deficiency anemia. It is due to vitamin B-12 deficiency.
Vitamin B-12 is necessary for the formation of Red blood cells. Pernicious anemia is mainly caused due to inability to absorb the vitamin B-12 by small intestine which is needed for our body to create red blood cells.
What is the difference between blood loss, pernicious and sickle anemia and describe their pathophysiology with references.
Describe the morphology of erythrocytes, the mechanism, and primary cause of the following anemias: Pernicious anemia, folate deficiency anemia, iron deficiency anemia, thalassemia, and sickle cell anemia.
Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule. Recall that hemoglobin carries oxygen in your red blood cells. The mutation causes these red blood cells to become stiff & sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of stroke, blindness, damage to the heart & lungs, and other conditions. Analyze...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
If both of John's parents are heterozygous for sickle cell anemia and Sarah's parents are AA and Aa what are the chances that John and Sarah's child will have Sickle Cell Anemia? (Sickle Cell Anemia is an autosomal recessive disease)
If a woman who is a carrier for sickle-cell anemia marries a man who is not a carrier, would any of their children get sickle-cell anemia? (Not sex-linked!) Prove it by doing a Punnett Square using the correct genotypes.
A mutation in one of the hemoglobin genes causes sickle cell anemia. The sickle cell allele, S, severely reduces fitness in people who are homozygotes, SS. In contrast, people with at least one normal hemoglobin allele, A, do not suffer the effects of sickle cell anemia, even if the individual is a heterozygote, AS. Interestingly, though, in areas with a high rate of malaria, heterozygotes that carry the sickle cell allele have a higher fitness than do individuals that are...
Why is electrophoresis with hemoglobin component of 86.5% HbS key test for sickle cell anemia? How is sickle cell anemia inherited? Why would reticulocyte percentage increase during a sickle cell attack?
In humans, sickle-cell anemia (HBBSHBBS) is caused by the recessive condition of an autosomal gene with two alleles: HBBA (wild-type) and HBBS (sickle-cell mutation). In one population, the frequency of individuals who do not suffer from sickle-cell anemia (HBBAHBBA and HBBAHBBS) is 0.9964. Assuming the population is in Hardy-Weinberg equilibrium, what is the frequency of the HBBS allele?
explain, in detail, the relationship between malaria and sickle-cell anemia. Why is having one sickle-cell allele considered a selective advantage? Is this equally beneficial for someone who is homozygous recessive for sickle-cell? Why or why not? Note: use specific vocabulary to describe your answers (genotype, homozygous d, homozygous r, natural selection, heterozygous, etc)