Question

2. List the trend of relative reactivity of compounds in: SN2 & SN1. Indicate which favors 1°, 2° or 3° carbon. 3. What makes a good leaving group, or poor leaving group in a substitution reaction? List examples. 4. What makes a good nucleophile or poor nucleophile group in a substitution reaction? List examples. Be able to identify the nucleophile in a reaction. 5. What makes a good solvent for an SN2 reaction? List examples. Assign R & S to structures including Fisher projections. Label pairs of stereoisomers as enantiomers, diastereomers, or identical. Identify chirality centers in a molecule. 6. 7. Nomenclature: Indicate stereochemistry (R, S) in structure or name for stereoisomers. Know how to draw stereoisomers [Example: (2S,3R)-dichlorobutane] in wedge-dash projection, Fisher projections, and also the most stable Newman projections (Note: You cannot show stereochemistry in Newman, only stability). 8. Reactions: Be able to provide structures for the reactants, intermediates, or products as indicated in the reactions. If two stereoisomers are produced, label each with R or S. 9. What conditions favor each reaction mechanism? i. Sl ii. S2 iii. El iv. E2

Answer 1

@ Good stable leaving group are those which become after leaning a ☺ Good No : Smaller size with higher Poor Mly : Bulky size of Muda og to to, & ett

6 Those solvent which are APROTIE nature are good for sne rana i in IS IN Les e 2 * > Polar proffic - Vent Solvent Polar Polar Botte aprotte solvent ? solvent vent Aprotte solvery Stow temp - low tempor High temp High temp weak to strong weak na strong NO Nuo vi bape how base stable = less hindered stess Corbeeantos san site Bulky substrate substate stes i Buplays