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Warfarin readily binds to plasma proteins such as albumin. Your colleague insists that this plasma protein...

Warfarin readily binds to plasma proteins such as albumin. Your colleague insists that this plasma protein binding allows warfarin to travel around the body better and helps to increase the distribution of the drug. Explain why your colleague is wrong in one sentence.

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Plasma protein binding of drug is the amount of drug that binds to protein in blood and form a protein+drug complex, this means that this complex is inactive form and cannot diffuse and exert effects on cells, and only amount of drug freely available in blood can be effective, thus, warfarin binds readily to plasma protein does not help it to diffuse into cells rather makes it stay in vestibular space and do not flow into tubular filtrate during excretion.

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