Diagnosis:
Diagnosis of measles based on the disease's characteristic rash as
well as a small, bluish-white spot on a bright red background —
Koplik's spot — on the inside lining of the cheek.If necessary, a
blood test can confirm whether the rash is truly measles.
Pathophysiology:
Measles is caused by a paramyxovirus and is a human disease with no known animal reservoir or asymptomatic carrier state. It is extremely communicable; the secondary attack rate is > 90% among susceptible people who are exposed.
Measles is spread mainly by secretions from the nose, throat, and mouth during the prodromal or early eruptive stage. Communicability begins several days before and continues until several days after the rash appears. Measles is not communicable once the rash begins to desquamate.
Transmission is typically by large respiratory droplets that are discharged by cough and briefly remain airborne for a short distance. Transmission may also occur by small aerosolized droplets that can remain airborne (and thus can be inhaled) for up to 2 hours in closed areas (eg, in an office examination room). Transmission by fomites seems less likely than airborne transmission because the measles virus is thought to survive only for a short time on dry surfaces.
An infant whose mother has immunity to measles (eg, because of previous illness or vaccination) receives antibodies transplacentally; these antibodies are protective for most of the first 6 to 12 months of life. Lifelong immunity is conferred by infection. In the US, almost all measles cases are imported by travelers or immigrants, with subsequent indigenous transmission occurring primarily among unvaccinated people.
Health promotion and disease prevention:
Measles vaccine in children
To prevent measles in children, doctors usually give infants the first dose of the vaccine between 12 and 15 months, with the second dose typically given between ages 4 and 6 years. Keep in mind:
Measles vaccine in adults
You may need the measles vaccine if you're an adult who:
If you're not sure if you need the measles vaccine, talk to your doctor.
Preventing measles during an outbreak or known infection
If someone in your household has measles, take these precautions to protect vulnerable family and friends:
Isolation. Because measles is highly contagious from about four days before to four days after the rash breaks out, people with measles shouldn't return to activities in which they interact with other people during this period.
It may also be necessary to keep nonimmunized people — siblings, for example — away from the infected person.
Risk factors :
Risk factors for measles include:
Expected findings :
Measles signs and symptoms appear around 10 to 14 days after exposure to the virus. Signs and symptoms of measles typically include:
The infection occurs in sequential stages over a period of two to three weeks.
Acute illness and rash. The rash consists of small red spots, some of which are slightly raised. Spots and bumps in tight clusters give the skin a splotchy red appearance. The face breaks out first.
Over the next few days, the rash spreads down the arms and trunk, then over the thighs, lower legs and feet. At the same time, the fever rises sharply, often as high as 104 to 105.8 F (40 to 41 C). The measles rash gradually recedes, fading first from the face and last from the thighs and feet.
Laboratory tests :
A complete blood count is unnecessary but, if obtained, may show leukopenia with a relative lymphocytosis.
Laboratory confirmation is necessary for public health and outbreak control purposes. It is most easily done by demonstration of the presence of measles IgM antibody in an acute serum specimen or by viral culture or RT-PCR of throat swabs, blood, nasopharyngeal swabs, or urine samples. A rise in IgG antibody levels between acute and convalescent sera is highly accurate, but obtaining this information delays diagnosis. All cases of suspected measles should be reported to the local health department even before laboratory confirmation.
Diagnostic procedures:
Clinical evaluation
Serologic testing
Viral detection via culture or reverse transcription–polymerase chain reaction (RT-PCR)
Typical measles may be suspected in an exposed patient who has coryza, conjunctivitis, photophobia, and cough but is usually suspected only after the rash appears. Diagnosis is usually clinical, by identifying Koplik spots or the rash in an appropriate clinical context. A complete blood count is unnecessary but, if obtained, may show leukopenia with a relative lymphocytosis.
Laboratory confirmation is necessary for public health and outbreak control purposes. It is most easily done by demonstration of the presence of measles IgM antibody in an acute serum specimen or by viral culture or RT-PCR of throat swabs, blood, nasopharyngeal swabs, or urine samples. A rise in IgG antibody levels between acute and convalescent sera is highly accurate, but obtaining this information delays diagnosis. All cases of suspected measles should be reported to the local health department even before laboratory confirmation.
Differential diagnosis includes rubella, scarlet fever, drug rashes (eg, resulting from phenobarbitalor sulfonamides), serum sickness (see Table: Some Causes of Urticaria), roseola infantum, infectious mononucleosis, erythema infectiosum, and echovirus and coxsackievirus infections (see Table: Some Respiratory Viruses). Manifestations can also resemble Kawasaki disease and cause diagnostic confusion in areas where measles is very rare.
Some of these conditions can be distinguished from typical measles as follows:
Rubella: A recognizable prodrome is absent, fever and other constitutional symptoms are absent or less severe, postauricular and suboccipital lymph nodes are enlarged (and usually tender), and duration is short.
Drug rashes: A drug rash often resembles the measles rash, but a prodrome is absent, there is no cephalocaudal progression or cough, and there is usually a history of recent drug exposure.
Roseola infantum: The rash resembles that of measles, but it
seldom occurs in children > 3 years of age. Initial temperature
is usually high, Koplik spots and malaise are absent, and
defervescence and rash occur simultaneously.
Nursing care :
Therapeutic procedures:
Medications :
Fever reducers. You or your child may also take over-the-counter medications such as acetaminophen (Tylenol, others), ibuprofen (Advil, Children's Motrin, others) or naproxen (Aleve) to help relieve the fever that accompanies measles.
Don't give aspirin to children or teenagers who have measles symptoms. Though aspirin is approved for use in children older than age 3, children and teenagers recovering from chickenpox or flu-like symptoms should never take aspirin. This is because aspirin has been linked to Reye's syndrome, a rare but potentially life-threatening condition, in such children.
Client education :
Interprofessional care :
Complications :
Complications of measles may include:
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