Homework Answers
#. Obesity is a condition that is associated with having an excess of body fat, defined by genetic and environmental factors that may impair health.
#. Pathophysiology :
complex interactions of genetics, environment and metabolism
- genetic problems include:
monogenic causes of obesity- such as mutations in the gene that codes for leptin (eats constantly)
Prader-willi syndrome - a defect in chromosome 15, which causes constant hunger and uncontrollable eating, among other clinical manifestations
FTO gene variants (fat mass and obesity-associated gene) SNPs- one of the variants increases obesity risk by 20-30%
#. Patho environmental factors
- abundance of foods filled with sugar, fat, and salt - trend of increased calories and trend of high fructose corn syrup
-increased portion size
- proliferation of fast food
#. Patho - adipocytes and adipose tissue
Adipocytes store fats, in the from of triglycerides. they also release triglycerides to be used for energy/fuel when needed
- under conditions of energy excess (energy intake >energy need), adipocytes can either: proliferate (hyperplasia) and hypertrophy (maladaptive response to energy excess
#. Risk factors :-
- Genetics
Genetics lay the foundation for obesity
If two parents are obese the child has an 80% chance, one parent 50% chance and zero overweight parents there is still an 10% chance.
- Sleep
Lack of sleep is linked to increased weight.
Lack of sleep leads to fatigue which means no physical activity and thus an increase in weight.
Sleep also helps manage hunger regulating hormones.
- Hormones
Defective hormone production in thyroid, pituitary or hypothalamus can change the way body burns and stores energy.
- Technology
Reduces physical activity
- Alcohol
Non-nutritive calories
- Bordem
Leads to overeating and greater energy consumption than energy expenditure
- Diet
A diest high in processed foods and low in whole foods (fibre) can lead to obesity.
#. Obesity has complications on many systems: list them.
Metabolic: eg, diabetes
Anatomic: eg, sleep apnea
Degenerative: eg, osteoarthritis
Neoplastic: eg, breast cancer
Psychological: eg, depression
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