Question

what 10 criteria can you differentiate these drugs

Bacitracin

Chloramphenicol

Meropenem

Polymxin B

Vancomycin

please mark them :)

Drug/Drug Grows Criteria 1 Criteria 2 Criteria 3 Criteria 4 Criteria 5 Criteria 6 Criteria 7 Criteria 8 Criteria 9 Criteria 10

Answer 1

Drugs	Class	Mechanism of action	Duration of action	Elimination	Distribution	Mode of administration	storage	Use in pregnancy	Spectrum of anti-microbial action	toxicity
Bacitracin	Polypeptide	inhibits bacterial cell wall synthesis	6 - 8 hrs	Renal	All body parts including ascitis and pleural effusion but not in CSF	topical and intramuscular	2 - 8 degree C	Category : C use with caution	Gram positive. little activity against gram negative	Nephrotoxicity
Chloramphenicol	Nitrobenzenes	Inhibits bacteria protein synthesis	half life - 1.5 to 3.5 hours	Urine and feces	all body parts and fluids including CSF and milk	topical and Intravenous	2 - 8 degree C	Category : C	gram positive, gram negative, spirochetes, Rickettsia	Bone marrow toxicity
Meropenem	Carbepenem	Inhibits baterial cell wall	After 6 hours of administration, the blood levels fall by 1mcg/hr	Renal > feces	Penetrates all tissues	Intravenous	room temperature	No fetal toxicity, but can be excreted in milk	Gram postive, gram negative, anaerobes, extended spectrum beta lactames producing organism -proteus, klebsialla, E.coli, H influenza	Hypersensitivity, clostridium difficle infection.
Polymyxin B	non ribosomal polycationic cyclic lipoproteins	Creates leaks in the cell membrane	4 - 6 hrs	Urine	doesnot enter aqueous humor, CSF, synovial fluid	topical Intravenous Intramuscular intrathecal	before reconstitution-15 - 30 degree C After reconstitution- 2-8 degreeC	Catergory : B animal studies donot show adverse effect but, humans studies are lacking	No activity against gram positive Active against acinetobacter klebsiella species Pseudomonas salmonella shigella E.coli Bordotella pertusis Anaerobes	hypersensitivity, nephrotoxicity, neurotoxicity
Vancomycin	glycopeptide	Inhibits cell call biosynthesis - blocks glycoprotein polymerization	4-6 hrs	urine	distributed everywhere except CSF	Oral and intravenous	Vial - 15 - 30 degree C After reconstitution - 2-8 degreeC Oral capsule - 15 -30 degreeC	effect on reproduction capacity unknown vancomycin is excreted in milk	Methicilin resistant staphlycoccus aureous Methicilin sensitive Staph aureus Enterococcus C.difficle	hypersensitivity, ototoxicity, hemorrhagic ooclusive retinal vasculitis