Question

Compare and contrast first and second generation antihistamines. Discuss at least one medication of each type. Include the indications, side effects, and any patient teaching.

Write an NCLEX style question on either type of medication discussed. Include the answer and rationale.  

Answer 1

Answer: First-Gen Gration Anth Histaminics Short - Intermediate Acting Frequent Dosing is required ③ Crosses Blood-brain barrier Havce, causes Sedation as Side Effect Acts on both-Central and Peopherd Histanivic - Receptors Second Generation Anti- Histanisics o longer Action is SEEN . Only 1 to 2 Doses are Sufficient & Doesn't cross blood-brain banier. Hence, No sedation in SEEN @ Acts only on Peripherd HistaninG Receptors . No fatality is seen yet with overdosing @ they are Newer Ones P Expensive Overdosing can be Lethal to Infant/youngs They are older Medicine Effective and in Expensive Examples - Chlorphenauanine Cyclizine Cyproheptadine Diphenhydraning Meclizine Promethazine & Examples - Cetrizine Levo CEterizine Fexofenadine Loratidine Desloratidine

3 Dry Eyes Drow siness Diphew hydranine: 1st Generation Antic Histaminic Indications Allergy Side-effects & Dry Mouth, Nose, throat ② May fever @ Constipation & Cough and Cold 6 Insomnia ③ Motion Sickness NCLEX Styled Questiow -> Q- A 43-year-old heavy Machine operator Complains of Seasonal allergies. Which one of the following medications would be most appropriate for Management of his Allergy Syruptores ? @ Cyclizine ④ Diphenhydranine © Cyproheptadine Fexofenadine Correct Ang =D Rationde: Use of 1st Gen Anti-histaminics is Contraindicated in the treatment of pilots and others professions where ONE Need to be Alert As fex of Enadine belong to 2nd Genertion Anti-histaminic Less So, Causes Sodation. Hence this is Correct Ans.
Summary- First Generation AntiHistamincs causes more Side effects of Sedation,Dry mouth,Dry Eyes,Contipation as The Act on muscarinic, Adrenergic Receptors as Well so Less preffered wheareas all these side- effects are less common with Second-Generation Anti-Hitaminics