Question

4. What specific adverse events can occur with the administration of aspirin in combination with certain other medications? Anti-lipemic Medications: 1. What are the main subclasses of antilipemic medications? 2. Describe, briefly, how each works. 3. What is the most clinically important adverse effect of HMG-CoA class of medications? Why is it so important? 4. How would you determine if a patient may be at risk for developing this adverse reaction? s. In order for atorvastatin to be most effective, when should it be administered? 6. What are the contraindications for bile acid sequestrant medications? 7. What do patients need to be taught about bile acid sequestrants and taking other prescribed medications? 8. For patients taking fibrates, what interaction would you consider the most important? 9. Long term use of anti-lipemic medications can result in what dietary issue? 10. How should a patient take niacin based anti-lipemic meds? 11. A patient taking niacin as an anti-lipemic medication complains about his face looking like his cheeks are sunburned. What would you tell him?

Answer 1

4.The action of aspirin is broader like it is a nonsteroidal anti inflammatory drug, antipyretics and can be used as a blood thinner too.Some of the adverse events which can occur when it is combined with other medications are

• When used with other pain killer it can lead to abdominal pain ,intestinal ulcers and bleeding
• If used with anticoagulant it can increase the risk for bleeding and changes in the clotting factors
• When it is taken along ACE inhibitors it can increase the risk for pulmonary and renal problems
• When taken with beta blocker it can affect the function of factor 8
• Acute renal failure, salicylate toxicity can occur when combined
• It has a great interaction like tinnitus if used with arthritic drugs
• Liver injury can occur if taken with methotrexate
• If taken with herbal supplements it can aggravate the action and cause side effects easily.