Under what circumstances could an exposure/disease association be causal without being biologically plausible?
Ans) Biological or social model exists to explain the
association. Association does not conflict with current knowledge
of natural history and biology of disease.
Many epidemiological studies have identified cause-effect
relationships before biological mechanisms were identified.
- Biological Plausibility
The proposed mechanism should be make sense given what we already
know about the agent, host and environment. CAVEAT just because we
don't yet understand the biological mechanism does not mean that
something is not causal.
Under what circumstances could an exposure/disease association be causal without being biologically plausible?
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