A patient (63kg) is treated with an experimental drug for hypertension. The drug is available as...
A patient (63kg) is treated with an experimental drug for hypertension. The drug is available as tablets with oral bioavailability of 88%. If the Vd is 2L/kg and the desired concentration is 2.8 mg/L, which of the following is the most appropriate oral loading dose for this drug?
|
207 mg |
||
|
400.9 mg |
||
|
110mg |
||
|
.4 mg |
||
|
613mg |
Homework Answers
ANSWER.
* Calculation of loading dose.
Formula
Loading dose = Vd(Volume of distribution) * (Target concentration)Tc / F(Bioavailablity).
Here
Volume of distribution = 2 L/kg
Volume of distribution for patient weight 63 kg = 2 * 63
= 126 L.
Target concentration = 2.8 mg/L.
Bioavailability = 88%
= 88/100
= 0.88.
As per above formula
Loading dose = 126 * 2.8 / 0.88
= 352.8 / 0.88
= 400.9 mg.
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