Drug A has a Vd of 0.65 L/kg. If target concentration TC = 20 mg/L, what is the appropriate loading dose for a 90kg pati...

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Drug A has a Vd of 0.65 L/kg. If target concentration TC = 20 mg/L, what is the appropriate loading dose for a 90kg pati...

Drug A has a Vd of 0.65 L/kg. If target concentration TC = 20 mg/L, what is the appropriate loading dose for a 90kg patient? Why would you want to use a loading dose?

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Answer 1

Answer #1

Loading dose = volume of distribution x target concentration

Loading dose = 0.65 x 20 = 13mg/kg

Loading dose can be defined as the initial drug dose which is slightly higher before starting the lower maintainence dose.

Loading dose is mainly given for drugs which eliminate slowly from the body. They require low maintainance dose.

Loading dose is used to achieve quick action

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Answer 2

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Drug A has a Vd of 0.65 L/kg. If target concentration TC = 20 mg/L, what is the appropriate loading dose for a 90kg pati...

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Drug A has a Vd of 0.65 L/kg. If target concentration TC = 20 mg/L, what is the appropriate loading dose for a 90kg pati...

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