A drug is eliminated by renal excretion and liver metabolism. The drug has an oral bioavailabilty...
A drug is eliminated by renal excretion and liver metabolism. The drug has an oral bioavailabilty of 0.9. Following a 100 mg oral dose administration, the total amount of drug recovered in urine was 60 mg. The half-life of this drug is 3.3 hours and its volume of distribution is 10 L. Calculate the total clearance, renal clearance and the constant of renal excretion (Kr) for this drug.
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A drug is eliminated by renal excretion and liver metabolism.
The drug has an oral bioavailabilty...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr. Co=...
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
could two is the volume that you have to mutlply to the cu to find the...
could two is the volume that you have to mutlply to the cu to
find the Au or amount in MG
its
not organic chemsitry its pharmacokinetics
Practice Chapter 5: Renal Excretion 1. After an intravenous injection of 1000 mg of a new drug to a patient, the following urinary and plasmatic information was obtained: Collection Interval (h) Urine Volume Concentration (mg/mL) in Urine Cp(tmid) (mg/L) 0-2 125 15.9 2-4 150 1.776 0.933 0.504 10.0 4-6 175 6.3 6-8 138...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
When 800 mg of a new drug under study is administered IV in normal volunteers, 800...
When 800 mg of a new drug under study is administered IV in normal volunteers, 800 mg are recovered unchanged in urine. The AUC obtained after IV injection is 400 mg.h/L and the half life is 8 hours. When 400 mg are orally administered in volunteers 350 mg of drug are recovered unchanged in urine. Calculate: K, Kr, Vd, and oral bioavailability (F). thats all the data i have
2. Renal Function and Dialysis Metabolism of protein in your diet produces urea as a byproduct....
2. Renal Function and Dialysis Metabolism of protein in your diet produces urea as a byproduct. The rate of urea production (r_u) depends on how much protein you eat and how big you are (measured by your body fluid volume, V). A realistic urea production rate for an average person (\/=40 L) is about r_u= 15 mg/min. Urea produced in the liver is rapidly distributed throughout the body's fluid volume V; the average urea concentration in the body's fluids is...
Please show work. A 86.5 kg patient has just received a single 500 mg oral dose...
Please show work.
A 86.5 kg patient has just received a single 500 mg oral dose of an antibiotic. This antibiotic has a 90% oral bioavailability, 8.6 hour elimination half-life, and a 1.1 hour absorption half-life. The drug literature states that the population volume of distribution is 1.1 L/kg for this medication. A blood sample was collected at the maximum drug concentration and reported to be 5.916 mg/L. What is the patient-specific volume of distribution of this antibiotic in this...
The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3...
The antiarrhythmic drug procainamide has the following characteristics: Therapeutic window 4 - 8 mg/L, half-life 3 hours, and volume of distribution 2 L/Kg. A 65 Kg patient requires an infusion in order to attain the plasmatic concentration of 6 mg/L. Recommend a loading dose and constant rate infusion (K0) for this treatment
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His...
An adult male (73 years old, 65 kg) with diabetes mellitus is placed on hemodialysis. His residual creatinine clearance is <5mL/min. The patient is given tobramycin, an aminoglycoside antibiotic, at a dose, at a dose of 1 mg/kg by IV bolus injection. Tobramycin is 90% excreted unchanged in the urine, is less than 10% to plasma protein, and has elimination half-life 2.2 hours in patient with normal renal function. In this patient, tobramycin has an elimination t1/2 of 50hours during...
please help me with this pharmokinetics problem: The study of a drug, after administration to experimental...
please help me with this pharmokinetics problem:
The study of a drug, after administration to experimental
animals of 500 mg solution intravenously in the form of bolus,
experimental data from the following table are obtained.
Time (hours)
Concenration (µg/mL)
0.5
17.52
1
13.52
2
8.28
4
3.05
6
1.12
8
0.41
12
0.06
Calculate a) elimination constant, b) distribution volume, c)
drug eliminationand clearance (in mL//min), d) area under the
curve, e) the biological half-life of this drug
the given...
The physician ordered a creatinine clearance for an inpatient that possibly has early onset of renal problems. The nurse...
The physician ordered a creatinine clearance for an inpatient that possibly has early onset of renal problems. The nurse was instructed to collect 24 hours of urine sample with a total volume of 950 ml. The plasma creatinine was analyzed from the specimen during the early morning draw along with Complete Metabolic Panel. The result was 3.5 mg/dL. The urine chemistry result was 185 mg/dl. Calculate the creatinine clearance in ml/min.
I know a is .458mg/L; b is 1.977hr; c is 368mg; d is 17.35 L/hr.
Co= 7.36mg/L and ke=.347 1/hr. I need help with E and F. I'm not
sure how to calculate them.
Q1. A drug is eliminated through glomerular filtration and hepatic metabolism. It does not bind to plasma proteins. Glomerular filtration rate is normal. The drug does not undergo active renal secretion and passive or active reabsorption after renal filtration is observed. The volume of distribution is...
could two is the volume that you have to mutlply to the cu to
find the Au or amount in MG
its
not organic chemsitry its pharmacokinetics
Practice Chapter 5: Renal Excretion 1. After an intravenous injection of 1000 mg of a new drug to a patient, the following urinary and plasmatic information was obtained: Collection Interval (h) Urine Volume Concentration (mg/mL) in Urine Cp(tmid) (mg/L) 0-2 125 15.9 2-4 150 1.776 0.933 0.504 10.0 4-6 175 6.3 6-8 138...
7. Smokers are known to have about 50% higher CL than nonsmokers for theophylline. If the average observed AUC after administration of 300 mg IV theophylline in nonsmokers is 100 mg.hr/L, what is the expected AUC in smokers after administration of the same 300 mg dose? Theophylline undergoes linear pharmacokinetics 2. After administration of a single 400 mg dose of a drug, a linear plot of the serum concentration-time prorile on a semi-log graph paper showed a y-intercept of 1mg/mL...
2. Renal Function and Dialysis Metabolism of protein in your diet produces urea as a byproduct. The rate of urea production (r_u) depends on how much protein you eat and how big you are (measured by your body fluid volume, V). A realistic urea production rate for an average person (\/=40 L) is about r_u= 15 mg/min. Urea produced in the liver is rapidly distributed throughout the body's fluid volume V; the average urea concentration in the body's fluids is...
Please show work.
A 86.5 kg patient has just received a single 500 mg oral dose of an antibiotic. This antibiotic has a 90% oral bioavailability, 8.6 hour elimination half-life, and a 1.1 hour absorption half-life. The drug literature states that the population volume of distribution is 1.1 L/kg for this medication. A blood sample was collected at the maximum drug concentration and reported to be 5.916 mg/L. What is the patient-specific volume of distribution of this antibiotic in this...
please help me with this pharmokinetics problem:
The study of a drug, after administration to experimental
animals of 500 mg solution intravenously in the form of bolus,
experimental data from the following table are obtained.
Time (hours)
Concenration (µg/mL)
0.5
17.52
1
13.52
2
8.28
4
3.05
6
1.12
8
0.41
12
0.06
Calculate a) elimination constant, b) distribution volume, c)
drug eliminationand clearance (in mL//min), d) area under the
curve, e) the biological half-life of this drug
the given...
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