Question

Drug potency and efficacy is compared with the use of a dose-response curve. Draw a dose response curve. Label and define the parameter that is used to assess potency and efficacy. Make sure to label both the y and the x-axis.

Answer 1

Drug potency and efficacy is compared with the use of a dose-response curve. Draw a dose response curve. Label and define the parameter that is used to assess potency and efficacy.

1. Efficacy
   • maximum effect that a drug can produce regardless of dose
2. Potency
   • amount of a drug that is needed to produce a given effect
     • e.g., EC50 is the concentration or dose of drug that causes 50% of maximum effect
   • determined by affinity of drug for receptor and number of receptors available

The difference between 'potency' (affinity) and 'efficacy' (activity) Efficacy difference Potency difference Log drug dose (concentration)

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