What is Burkitt’s lymphoma? Describe the pathophysiology and how it affects the immune system.
#. Burkitt lymphoma is a form of non-Hodgkin's lymphoma in which cancer starts in immune cells called B-cells. Recognized as the fastest growing human tumor, Burkitt lymphoma is associated with impaired immunity and is rapidly fatal if left untreated. There are three types of Burkitt lymphoma :-
- endemic
- sporadic
- immunodeficiency associated
#. Pathophysiology :-
All types of Burkitt lymphoma are characterized by dysregulation of the c-myc gene by one of three chromosomal translocations.This gene is found at 8q24.
The most common variant is t(8;14)(q24;q32), which accounts for about 85% of cases. This involves c-myc and IGH@. A variant of this, a three-way translocation, t(8;14;18), has also been identified.
A rare variant is at t(2;8)(p12;q24).This involves IGK@ and c-myc.
Another rare variant is t(8;22)(q24;q11).This involves IGL@ and c-myc.
What is Burkitt’s lymphoma? Describe the pathophysiology and how it affects the immune system.
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