a, Anticholinergic drug overdose can cause toxicity it includes
tachycardia, flushed face, blurred vision, dry mouth, fever,
trouble breathing, etc. Anticholinergic medications block the
neurotransmitter action and reduce the acetylcholine from causing
involuntary muscle movement in the lung, urinary tract, GI system,
etc.
b, When there is too little Acetylcholine at the central nervous
system and peripheral muscarinic receptors, it causes side effects.
Muscarinic receptors are Autonomic neurons involve in cholinergic
signals in CNS. muscarine and anticholinergic are prototypical
agonists and antagonists for receptor class. It is the main
receptor stimulated by acetylcholine released from postganglionic
fibers in the parasympathetic nervous system.
c, Action of the inhibition can increase the level of acetylcholine
and inhibit the enzyme(choline esterase) it prevents the excess
acetylcholine formation. Physostigmine, neostigmine, and
pyridostigmine are anticholine esterases it acts in the CNS has
solubility and ionization. this enzyme inhibit the enzyme so
acetylcholine increase at the neuroreceptor site.
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