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how long does the anit-platelet effect last for aspirin?

how long does the anit-platelet effect last for aspirin?
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Answer #1

Aspirin is the derivative of acetylates and inhibits the enzyme cyclo oxygenese COX1 and inactivate them irreversibly .Because platelets are exposed to aspirin in the portal circulation before it is deacetylated during first pass in the liver and because platelets cannot synthesize fresh enzyme formation which is suppressed at very low doses and till fresh platelets are formed .

Thus aspirin induced prolongation of bleeding time lasts for 5-7days . Effect of daily doses cumulates and doses shows the lowest doses as 40 mg /day.

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