What would happen to the signaling pathway if the receptor were mutated? What about if the...
What would happen to the signaling pathway if the receptor were mutated? What about if the hormone was mutated?
Homework Answers
Let us take the example of the G-protein coupled receptor in the cAMP signaling pathway.
- In normal functioning, binding of the hormone leads to the interaction of the receptor with G protein, which activates the alpha subunit of the G protein. This alpha subunit then stimulates adenylyl cyclase, which converts ATP to cAMP.
- If the receptor were mutated, the receptor may not recognize the hormone and not bind to it. Another possible case is that on binding with the hormone, the receptor activates some other subunit of the G protein and not lead to the stimulation of adenylyl cyclase, leading to the disruption of ATP to cAMP conversion.
- If the hormone were mutated, then it won't bind to the receptor and no cAMP pathway will take place.
Add Answer to:
What would happen to the signaling pathway if the receptor were
mutated? What about if the...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of...
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain? What are the analogous activating signals downstream of receptor activation in the GPCR and RTK pathways.
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of...
What is the key activating signal in the TNF receptor signaling pathway that occurs downstream of TNF-alpha binding to the extracellular domain? What are the analogous activating signals downstream of receptor activation in the GPCR and RTK pathways.
Name a signaling pathway that is activated by toll-like receptor recognition of PAMPS that is independent...
Name a signaling pathway that is activated by toll-like receptor recognition of PAMPS that is independent of the pathway leading to INF expression (A) and describe the outcome of activation of this pathway (B).
How is signaling from receptor tyrosine kinases terminated? GTP hydrolysis ATP hydrolysis receptor endocytosis Arrestins Pathway...
How is signaling from receptor tyrosine kinases terminated? GTP hydrolysis ATP hydrolysis receptor endocytosis Arrestins Pathway crosstalk occurs when: signaling pathways use a common intermediate o signaling pathways split to produce multiple outcomes one signaling pathway triggers another signaling pathways produce the same outcome Eicosanoid hormones such as prostaglandins and leukotrienes are responsible for localized immune reactions such as to insect bites and hayfever symptoms. Which of the following best describes this level of cell signaling? Autocrine Endocrine o Holoerine...
The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling...
The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...
1) General pathway for receptor-ligand signaling in B and T cells? 2) Differences between TCR and...
1) General pathway for receptor-ligand signaling in B and T cells? 2) Differences between TCR and immunoglobulin (what they bind & structure)? please keep the answers short! Thankyou.
Which of the following is a TRUE statement about hormone signaling?
Which of the following is a TRUE statement about hormone signaling? A hormone can cause an effect in a cell without binding to its receptor. Most hormone receptors interact with multiple types of hormones. A hormone always causes the same effect in different cell types. Interaction of a hormone with its receptor alters the activities of many enzymes in a cell.
Research and describe a cell receptor involved in cell signaling that utilizes one of the following...
Research and describe a cell receptor involved in cell signaling that utilizes one of the following mechanisms. 1. RTK pathway (Receptor Tyrosine Kinase Cascade) 2. GPCR (G Protein Coupled Receptor) 3. Ion Channel Receptors 4. Ligand Gated Your summary of the protein receptor must include the following: 1. Name of the receptor and its ligand. 2. A brief description of the pathway (what is activated and how). 3. Name of the pathway it is responsible for activating and what the...
I would prefer if you described the PERK signaling pathway out of the 3. Thanks! The...
I would prefer if you described the PERK signaling pathway out
of the 3. Thanks! The figure might help.
Describe in detail 1 (out of the 3) ER stress signaling pathways. Include all of the signaling components of the pathway [ligand, receptor, secondary signaling molecule(s), effector(s), cellular response, etc.) and their specific function. m BiP BIP BiP PERK IRE1 ATF6 ER 33333333 Cytosol Translocation to Golgl, cleavage by S1P and S2P Constant degradation elF2a Nrf2 ) Keap! XBP1s ATFO Dissociation...
Activity 4. Receptor signaling pathway A model of a G protein receptor signaling pathway is represented below. Activation of the signaling pathway results in a cell secreting a neurotransmitter through exocytosis. Activated - Activated adenylyl receptor cyclase GTP АТР CAMP Active G protein Protein- kinase A Inactive Active Protein targets Phosphate group A. Different steps in a signaling pathway can amplify the initial signal of one ligand binding to one receptor. Choose one step in the pathway below that results...
How is signaling from receptor tyrosine kinases terminated? GTP hydrolysis ATP hydrolysis receptor endocytosis Arrestins Pathway crosstalk occurs when: signaling pathways use a common intermediate o signaling pathways split to produce multiple outcomes one signaling pathway triggers another signaling pathways produce the same outcome Eicosanoid hormones such as prostaglandins and leukotrienes are responsible for localized immune reactions such as to insect bites and hayfever symptoms. Which of the following best describes this level of cell signaling? Autocrine Endocrine o Holoerine...
The small monomeric G protein Ras is an important component of most receptor tyrosine kinase signaling pathways. It can regulate a number of downstream signaling components, perhaps most famously the MAPK cascade. Unlike other monomeric G proteins that we have discussed previously in class, Ras is anchored at the plasma membrane by a covalently bound lipid anchor. If Ras was specifically mutated so that it did not get this lipid modification (but was otherwise completely unchanged), what do you hypothesize...
I would prefer if you described the PERK signaling pathway out
of the 3. Thanks! The figure might help.
Describe in detail 1 (out of the 3) ER stress signaling pathways. Include all of the signaling components of the pathway [ligand, receptor, secondary signaling molecule(s), effector(s), cellular response, etc.) and their specific function. m BiP BIP BiP PERK IRE1 ATF6 ER 33333333 Cytosol Translocation to Golgl, cleavage by S1P and S2P Constant degradation elF2a Nrf2 ) Keap! XBP1s ATFO Dissociation...
Most questions answered within 3 hours.
-
The factory method and the abstract factory pattern use
different object oriented
mechanisms are used to...
asked 3 hours ago -
Given the data below for the monthly sales data at each branch in
your region for...
asked 3 hours ago -
Blossom Company owns 10000 of the 50000 outstanding shares of
Taylor, Inc. common stock. During 2018,...
asked 5 hours ago -
Calculate the following: ***SHOW ALL WORK!!!! Or
NO CREDIT*** Circle your answers. 8pts
each
In the...
asked 6 hours ago -
Bank Z is currently advertising interest rates on its checking
account. They claim to pay an...
asked 6 hours ago -
List two ways of transformation on the response variable that
can be used to deal with...
asked 7 hours ago -
If a 2000 ohm resistor has a -3.90 mA current going through it.
What is the...
asked 7 hours ago -
Please comment on the sentences.
Some types of jobs require more training than others. Some
companies...
asked 8 hours ago -
The )G01 for the hydrolysis of phosphorarginine
reaction depicted below is –32 kJ mol-1.
Phosphoarginine ...
asked 9 hours ago -
Cross a heterozygous blue-eyed goat with a homozygous brown-eyed
goat. Be sure to indicate which kids...
asked 9 hours ago -
Use the following information to answer the next two
questions.
Please refer to question 9-90. A...
asked 9 hours ago -
A solution containing 0.050 g of an unknown electrolyte in 2.50
g of cyclohexane was found...
asked 9 hours ago