Why might inhibition of LDH in cancer cells lead to cancer cell death? Explain why conjugating...
Homework Answers
Lactate dehydrogenase (LDH) is important enzyme for tumor cell metabolism catalyzing the conversion of pyruvate to lactate. This step is necessary because it regenerate NAD+, which is needed to continue glycolysis and ATP production even in the absence of aerobic oxidation of NADH. So, inhibition of LDH inhibits glycolysis leading to death of cancer cells.
Cancerous tissues consume large amounts of glucose compared to normal tissue.They show very high rates of aerobic glycolysis. This phenomenon is also known as the Warburg effect. Lactate dehydrogenase (LDH) being a Glycolytic enzyme, are widely overexpressed in human cancers and high expression levels of these makes them attractive therapeutic targets by using glycoconjugation (conjugating an LDH inhibitor to glucose) to selectively target anticancer therapeutics to cancer cells. Furthermore, LDH inhibition is unlikely to harm normal tissues. Hence, conjugation of an LDH inhibitor to glucose leads to preferential targeting of cancer cells.
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Why might inhibition of LDH in cancer cells lead to cancer
cell death?
Explain why conjugating...
What type of cell death is most often induced in cancer cells by radiation and chemotherapy...
What type of cell death is most often induced in cancer cells by radiation and chemotherapy drugs? Why is this? (ie- which factor is often missing in cancer cells?)
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make...
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
How might the loss of components of the apoptosis machinery render cancer cells more susceptible than...
How might the loss of components of the apoptosis machinery render cancer cells more susceptible than normal cells to certain types of cell death?
Knowing that FAS death receptor was activated in cholesterol depleted cancer cells. Explain how activation of...
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Why is it important to understand the cell cycle when considering cancer? In your answer, explain...
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A suspension of yeast cells is being grown under anaerobic conditions such that glucose is degraded...
A suspension of yeast cells is being grown under anaerobic conditions such that glucose is degraded to ethanol and carbon dioxide. Adding an inhibitor of alcohol dehydrogenase to the yeast cell suspension results in rapid cell death. Why? a.) Without alcohol dehydrogenase, the acetaldehyde concentration increases to levels that are toxic to the yeast cells. b.) NADH generated during glycolysis cannot be recycled back to NAD+, thus anaerobic ATP production through glycolysis cannot be maintained. c.) Pyruvate is no longer...
1. Why do cancer cells rely so much on metabolism of glucose ? A. Because cancer...
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Depletion of cholesterol in the cell membrane using a drug (mevastatin) has been associated with apoptosis in cancer cells. a. What effect would cholesterol depletion have on the integrity of lipid ra...
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Question 31 2.3 pts What feature characterizes cancer cells? carefully regulated cell cycle uncontrollable cell division...
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Cancer cells typically have less cholesterol and more phospholipid in their cell membranes. This phenotype is...
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Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
Question 31 2.3 pts What feature characterizes cancer cells? carefully regulated cell cycle uncontrollable cell division respond to density-dependent and anchorage dependent inhibition o divide by meiosis produce cells which are different from themselves
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