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13. In a few words each, describe one of the 2 the features of the ITAM that make it perfectly suited to bind tandem SH2 domains. [2 pts]

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The characteristics of this binding is featured by T cell receptor CD3 epsilon subunit of the ITAM. The main feature of this peptide subunit which aids in the binding is its affinity rate of 18-81 nM at 150mM NaCl over the 4.5 - 30 degrees centigrade temperature range.The temperature dependence plays a key role. The two features are:

  1. This helps in the on rate constant for the increase in the affinity of binding.
  2. The fluorescence of Syk-tSH2 and its CD3 epsilon peptide comples.
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