Question

Question 20 (1 point) Figure out the mutation. You will need the codon table to answer this question. Wild type genomic sequence of a portion of a gene and the wild type sequence of portion of the protein gene product. The protein sequence only matches partially. TAT AAA GGG CGA CCA CCT GGT AAT GGG ACT TTG AGG Tyr Lys Gly Arg Pro Pro Ala Pro Arg Gin Tyr Trp Note: The five amino acids at the amino end of the WT protein match the coding sequence perfectly, but not the six at the carboxyl end. This is for an obvious reason that you should figure out before starting the problem. One of the difficulties with this problem is that you do not have the DNA sequence for the carboxyl end of the protein, but that should not be a problem! And, so far, there are no mutations; nothing unusual, it is just a normal eukaryotic gene!! A mutant is found that has the following protein sequence in that part of the protein: Tyr Lys Gly Arg Pro Pro Gly Met Gly Leu Stop. What is the likely mutation? O between A12 and C13 insert T. Obetween C13 and C14 insert T. OA15 -> del. O c13 and C14 -> del. O G8 -> T. O G20 -> A. OT21 -> del. O Digital copy: TAT AAA GGG CGA CCA CCT GGT AAT GGG ACT TTG AGG

Answer 1

T21. deleted

Frame shift mutation;

starting from 19

GGA ATG GGA CTT TGA

gly met gly leu stop