Why are some cells eliminated and some cells survive in negative selection for immature B cells?
Why are some cells eliminated and some cells survive in negative selection for immature B cells?
Homework Answers
Answer
When Immature B cells produce high-affinity auto antibodies against self-antigen during maturation phase in bone marrow fails to complete maturation and undergoes elimination, it is known as negative selection of immature B cells.
Negative selection basically ensures that B cells are tolerant to self-antigens.When immature B cells express surface IgM that recognizes ubiquitous self-cell-surface antigens, then they are eliminated and these B cells are believed to undergo programmed cell death or apoptosis.
When Immature B cells that bind soluble self-antigens do not die but their ability to express IgM on their surfaces is lost. Thus, they migrate to the periphery only expressing IgD and are unable to respond to antigen and these B cells are called anergic.
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Why are some cells eliminated and some cells survive in negative
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