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In order to survive negative selection and exit the thymus, single-positive T cells must express: answers:...

  1. In order to survive negative selection and exit the thymus, single-positive T cells must express:

answers:

a. both CD4 and CD8

b. IL-2 receptor (CD25) and CTLA-4

c. TCR which have high affinity for self-antigen

d. both an alpha-beta and gamma-delta TCR on the cell surface

e. TCR which have weak affinity for self-antigen

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Answer #1

In this case, the correct answer is both CD4 and CD8. Of course, they wont be expressed at the same time on a single T cell. There will be two types of cells that survives to the positive selection: T-CD4 and T-CD8. In the negative selection the will be in contact with the complex MHC in order to determinate self reacting T cells. If they survive to this selection, newly T-CD4 and T-CD8 cells will exit the thymus.

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