Homework Answers
Answer: Negative selection occurs when double positive T cells bind to bone-marrow derived APC (macrophages and dendritic cells) expressing Class I or Class II MHC plus self peptides with a high enough affinity to receive an apoptosis signal, thereby eradicating immature T cell that have a high likelihood of being self-reactive and attacking our own cells.
So, during negative selection MHC class I and II molecules on the surface of thymic epithelial cells Present only peptides derived from self MHC molecule.
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During negative selection MHC class I and Il molecules on the surface of thymic epithelial cells...
Could you help with any of these ? and provide an explanation so I'll understand? thank...
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
Upregulation of MHC class Il molecules on the surface of antigen-presenting cells occurs during infection. What...
Upregulation of MHC class Il molecules on the surface of antigen-presenting cells occurs during infection. What is this aided by? Select one: a. Destablization of the interaction between the invariant chain and MHCl in the ER O b. Accumulation of HLA-DO in response to inflammatory cytokines c. Deacidification of endocytic vesicles d. IFN-V induced expression of HLA-DM, but not HLA-DO
In the absence of infection ____________________ (Select all that apply). 1. MHC class I and class...
In the absence of infection ____________________ (Select all that apply). 1. MHC class I and class II molecules bind to and transport self peptides to the cell surface 2. MHC class I and class II molecules are unable to progress through the vesicular system 3. MHC class II molecules bind to self peptides prematurely in the lumen of the endoplasmic reticulum 4. non-self peptides do not bind to MHC molecules Please select all correct answers. Thank you.
In the absence of infection ____________________ (Select all that apply). 1. MHC class I and class...
In the absence of infection ____________________ (Select all that apply). 1. MHC class I and class II molecules bind to and transport self peptides to the cell surface 2. MHC class I and class II molecules are unable to progress through the vesicular system 3. MHC class II molecules bind to self peptides prematurely in the lumen of the endoplasmic reticulum 4. non-self peptides do not bind to MHC molecules
The immune system is self-restricted and the self-restriction is seen with immunological responses that involve both the MHC class I and the MHC class II molecules. Define MHC class I and class II res...
The immune system is self-restricted and the self-restriction is
seen with immunological responses that involve both the MHC class I
and the MHC class II molecules. Define MHC class I and class II
restriction, which molecules and cells are involved and which stage
of the immune response (stages 1 – 8 in figure 1-7) the class I and
class II restriction occurs (pick a stage from figure 1-7, state
that stage, and describe the MHC restriction taking place (class I...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!! 1) A patient has inherited two defective genes for...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
Question 13 3 pt: MHC I and MHC Il differ from each other in that: MHC...
Question 13 3 pt: MHC I and MHC Il differ from each other in that: MHC I, but not MHC II, is necessary for T cells to kill cells presenting endogenous antigen MHC I, but not MHC II, primarily present exogenous antigens to CD8+ T cells MHC I, but not MHC II, is necessary for T cells to activate B cells MHC II, but not MHC I, primarily present endogenous antigens to CD4+ T cells Question 14 3 pts In...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from the cytosol into the endoplasmic reticulum, where they can associate with newly translated Class la chains O B-2 microglobulin. Proteosomes. Immunoglobulin molecules. Class Il a and B chains. Question 20 5 pts Soluble proteins are examples of: Bone marrow dependent antigens. Bone marrow independent antigens., Thymus dependent antigens. Thymus independent antigens. Good food. The features of bound peptide fragments isolated from different class molecules...
Immunology The immune system is self-restricted and the self-restriction is seen with immunological responses that involve both the MHC class I and the MHC class II molecules. Define MHC class I and c...
Immunology
The immune system is self-restricted and the self-restriction is
seen with immunological responses that involve both the MHC class I
and the MHC class II molecules. Define MHC class I and class II
restriction, which molecules and cells are involved and which stage
of the immune response (stages 1 – 8 in figure 1-7 on page 20) the
class I and class II restriction occurs (pick a stage from figure
1-7, state that stage, and describe the MHC restriction...
In order to survive negative selection and exit the thymus, single-positive T cells must express: answers:...
In order to survive negative selection and exit the thymus, single-positive T cells must express: answers: a. both CD4 and CD8 b. IL-2 receptor (CD25) and CTLA-4 c. TCR which have high affinity for self-antigen d. both an alpha-beta and gamma-delta TCR on the cell surface e. TCR which have weak affinity for self-antigen
Could you help with any of these ? and provide an explanation
so I'll understand? thank you so much
Circle all that apply 1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules...
Upregulation of MHC class Il molecules on the surface of antigen-presenting cells occurs during infection. What is this aided by? Select one: a. Destablization of the interaction between the invariant chain and MHCl in the ER O b. Accumulation of HLA-DO in response to inflammatory cytokines c. Deacidification of endocytic vesicles d. IFN-V induced expression of HLA-DM, but not HLA-DO
The immune system is self-restricted and the self-restriction is
seen with immunological responses that involve both the MHC class I
and the MHC class II molecules. Define MHC class I and class II
restriction, which molecules and cells are involved and which stage
of the immune response (stages 1 – 8 in figure 1-7) the class I and
class II restriction occurs (pick a stage from figure 1-7, state
that stage, and describe the MHC restriction taking place (class I...
ANSWER ALL THE QUESTIONS FULLY AND CORRECTLY!!!
1) A patient has inherited two defective genes for TAP2 (remember the case study from before) Which of the following are true? (circle all that apply): - The patient will have a scarcity of CD4+ T helper cells -MHC class I molecules will not be expressed to any extent on the patient's cells -MHC class II molecules will be reduced in expression - The patient will have an impaired ability to fight viral...
Question 13 3 pt: MHC I and MHC Il differ from each other in that: MHC I, but not MHC II, is necessary for T cells to kill cells presenting endogenous antigen MHC I, but not MHC II, primarily present exogenous antigens to CD8+ T cells MHC I, but not MHC II, is necessary for T cells to activate B cells MHC II, but not MHC I, primarily present endogenous antigens to CD4+ T cells Question 14 3 pts In...
The transporter in antigen processing genes encode subunits of a heterodimer pump that transports peptides from the cytosol into the endoplasmic reticulum, where they can associate with newly translated Class la chains O B-2 microglobulin. Proteosomes. Immunoglobulin molecules. Class Il a and B chains. Question 20 5 pts Soluble proteins are examples of: Bone marrow dependent antigens. Bone marrow independent antigens., Thymus dependent antigens. Thymus independent antigens. Good food. The features of bound peptide fragments isolated from different class molecules...
Immunology
The immune system is self-restricted and the self-restriction is
seen with immunological responses that involve both the MHC class I
and the MHC class II molecules. Define MHC class I and class II
restriction, which molecules and cells are involved and which stage
of the immune response (stages 1 – 8 in figure 1-7 on page 20) the
class I and class II restriction occurs (pick a stage from figure
1-7, state that stage, and describe the MHC restriction...
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