Question

Explain the regulation of the enzyme glutamate dehydrogenase & discuss the physiological significance of this regulation.

Answer 1

Regulation of glutamate dehydrogenase:- In humans, the activity of glutamate dehydrogenase is controlled through ADP-ribosylation, a covalent modification carried out by the gene sirt4. This regulation is relaxed in response to caloric restriction and low blood glucose.

Explaination:- Glutamate dehydrogenase (GDH) generally catalyzes the reversible inter- conversion of glutamate to a- ketoglutarate and ammonia. High levels of GDH activity is found in mammalian liver, kidney, brain, and pancreas. Glutamate dehydrogenase is defined as an enzyme catalysing reaction for ammonium immersion, an another way to those functioned by glutamine synthetase and glutamate synthase. Glutamate dehydrogenase (GDH) is located in the mitochondria and is an important branch- point enzyme between carbon and nitrogen metabolism. GDH catalyzes the reversible NAD (P)+-linked oxidative deamination of L-glutamate into alpha ketoglutarate and ammonia in two steps. Glutamine synthetase, referred to for brevity as GS, catalyzes the amidation of glutamate to glutamine. Glutamine is of major importance in a variety of biosynthetic pathways including the synthesis of proteins, mucopolysaccharides, and nucleic acids.