Question

Which of the following statements about the unfolded protein response (UPR) in the endoplasmic reticulum (ER) and Adult- Onset (Type II) diabetes is false? Answers A-D A All of these statements are correct. o B An unfolded protein response in reaction to increased insulin demand can result in programmed cell death in insulin-producing cells of the pancreas leading to Type Il diabetes. C High levels of insulin production can lead to the accumulation of misfolded proteins in the ER, inducing the UPR. D Activation of the UPR results in the production of increased amounts of ER and the inhibition of translation, as well as increased chaperone production O

Answer 1

The correct answer is- C

Explanation- The unfolded protein response is a cellular response to the increased amount of unfolded proteins inside the ER lumen. This happens when there is a large demand of insulin production to counterbalance the elevated sugar level. The result is the accumulation of error-proteins inside the ER, which thereby triggers the UPR response in th cells. These misfolded proteins induce ER stress that , ultimately may lead to cell apoptosis(pancreatic beta cell apoptosis) and thereby induce the development of diabetes.