Question

3. Label the following statements about the unfolded protein response (UPR) as either true or false....

3. Label the following statements about the unfolded protein response (UPR) as either true or false. If it is FALSE, explain why it is false.

a. Activation of the UPR results in the production of more ER membrane.

b. Activation of the UPR results in the production of more chaperone proteins.

c. Activation of the UPR occurs when receptors in the cytoplasm sense misfolded proteins.

d. Activation of the UPR results in the cytoplasmic activation of gene regulatory proteins.

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Answer #1

a. Activation of the UPR results in the production of more ER membrane. - True

b. Activation of the UPR results in the production of more chaperone proteins. - True

c. Activation of the UPR occurs when receptors in the cytoplasm sense misfolded proteins. - False

This is not true. The truth is - Activation of the UPR occurs when receptors in the ER membrane sense misfolded proteins. It involves homodimerization, autophosphorylation, and activation of receptor in ER membrane.

d. Activation of the UPR results in the cytoplasmic activation of gene regulatory proteins. - True

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