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1,3-bisphosphoglycerate is one of the two phosphoryl group donors in the synthesis of ATP during glycolysis....
QUESTION 28 1,3-bisphosphoglycerate is one of the two phosphoryl group donors in the synthesis of ATP...
QUESTION 28 1,3-bisphosphoglycerate is one of the two phosphoryl group donors in the synthesis of ATP during glycolysis, in human erythrocytes, the steady-state concentration of ATP is 2.24 mM ADP IS 0.25 mm, and 3-phosphoglycerate is 0.12 mm. Calculate the concentration of 13. bisphosphoglycerate at 25°C, assuming that the phosphoglycerate kinase reaction) is at equilibrium in the cell. (Standard delta G=-18.9). 5.3E-7M 5.1E-5M 3.4E-6 M QUESTION 30 Why is the glyoxylate cycle critical for the growth and development of young...
3. The reaction in gluconeogenesis that converts 3-phosphoglycerate to 1,3-bisphosphoglycerate is at right. The AGC for...
3. The reaction in gluconeogenesis that converts 3-phosphoglycerate to 1,3-bisphosphoglycerate is at right. The AGC for this reaction is +18.9 kJ/mol. H-C-OH o HC - H-C-OH H2C 0 ATP ADP P-O 0 3-phosphoglycerate 1,3-bisphosphoglycerate a) What is the concentration of 3-phosphoglycerate under standard state conditions? b) In the hepatocyte, this reaction is near equilibrium. What is the AG in the cell? c) What is the ratio of products-to-reactants for this reaction in the hepatocyte? Assume the temperature is 25°C (298...
Tautomerization of enolpyruvate to pyruvate occurs in step 10 of glycolysis. If DG°’ = -46 kJ/mol,...
Tautomerization of enolpyruvate to pyruvate occurs in step 10 of glycolysis. If DG°’ = -46 kJ/mol, what is the ratio of pyruvate to enolpyruvate at equilibrium? Steady-State Concentrations of Glycolytic Metabolites in Erythrocytes Metabolite mM Glucose 5.0 Glucose-6-phosphate 0.083 Fructose-6-phosphate 0.014 Fructose-1,6-bisphosphate 0.031 Dihydroxyacetone phosphate 0.14 Glyceraldehyde-3-phosphate 0.019 1,3-Bisphosphoglycerate 0.001 3-Phosphoglycerate 0.12 2-Phosphoglycerate 0.030 Phosphoenolpyruvate 0.023 Pyruvate 0.051 Lactate 2.9 ATP 1.85 ADP 0.14 Pi 1.0
5. During step six of glycolysis glyceraldehyde-3-phosphate (G3P) is converted to 1,3- bisphosphoglycerate (1,3-BPG) and NAD+...
5. During step six of glycolysis glyceraldehyde-3-phosphate (G3P) is converted to 1,3- bisphosphoglycerate (1,3-BPG) and NAD+ is converted to NADH. (You can ignore the concentration of protons in the upcoming calculation.) G3P + P + NAD+ = 1,3 - BPG + NADH + H+ In the human erythrocyte, the concentration of G3P is 0.019 mm, the concentration of 1,3-BPG is 0.001 mM, the concentration of P, is 1.0 mm, and the ratio of NAD+ to NADH is 1000 to 1....
Glycolysis activity 1: Metabolic pathway puzzle Try to complete the activity without using the textbook. 1....
Glycolysis activity 1: Metabolic pathway puzzle Try to complete the activity without using the textbook. 1. Slides 4 and 5 show the 10 reactions for glycolysis, but some of the molecules are missing. Draw the missing molecules in the proper place (on the handout). The missing molecules are shown on the next slide, you have to use the clues on the handout and your organic chemistry knowledge to figure out where each molecule belongs. 3. In the red dotted boxes...
SOS 4 & 5 bo V/pid. 2137185-at-content-na-15926494-2/courses/CHEM400,01-FA2018/CHEM400%20F18%2 4. When the glucocorticoid receptor binds to its receptor...
SOS 4 & 5
bo V/pid. 2137185-at-content-na-15926494-2/courses/CHEM400,01-FA2018/CHEM400%20F18%2 4. When the glucocorticoid receptor binds to its receptor in the el... a. what is the effect of this binding on the expression of the Annexin I gene? b. what is the effect of this binding on the expression of the CoX-2 gene? c. what is the net effect on inflammation? 5. In step 7 of glycolysis, 1,3-BPG (1,3-bisphosphoglycerate) is converted into 3-PG (3- phosphoglycerate), and ATP is synthesized. The AG for this...
Concentrations of some glycolysis intermediates in the red blood cell (mM): Glucose Glucose-6-P Fructose-6-P Fructose-1,6-BP 1,3-bisphosphoglycerate...
Concentrations of some glycolysis intermediates in the red blood cell (mM): Glucose Glucose-6-P Fructose-6-P Fructose-1,6-BP 1,3-bisphosphoglycerate 0.001 3-phosphoglycerate 5.0 0.083 0.014 0.031 2- phosphoglycerate Phosphoenolpyruvate Pyruvate ATP ADP Pi 0.030 0.023 0.051 1.85 0.14 1.0 0.12 3. Isotopic labeling (incorporating a rare isotope, eg. the radioactive 1C, into a molecule at a defined position) is an important technique for studying metabolism as it enables us to follow individual atoms through a metabolic pathway 2 a. If 4CO2 were bubbled through...
1. 2. 3. 4. Select all that apply. Identify the reaction(s) of glycolysis inhibited by ATP □ glyceraldehyde-3-phosphate → 1,3-bisphosphoglycerate phosphoenolpyruvate +pyruvate 3-phosphoglycerate...
1.
2.
3.
4.
Select all that apply. Identify the reaction(s) of glycolysis inhibited by ATP □ glyceraldehyde-3-phosphate → 1,3-bisphosphoglycerate phosphoenolpyruvate +pyruvate 3-phosphoglycerate ~2-phosphoglycerate 1) fructose-6-phosphate→ fructose-1,6-bisphosphate . glucose glucose-6-phosphate Select all that apply. Alcohol fermentation: consumes ATP as it produces ethanol. O produces carbon dioxide begins as pyruvate is decarboxylated to acetaldehyde in a reaction catalyzed by alcohol dehydrogenase m regenerates NAD requires the enzyme alcohol dehydrogenase, In the figure below, what is the reaction occurring at the location...
Substrate Level phosphorylation occurs during glycolysis... step 6, during the formation of 1,3 bisphosphoglycerate from GAP...
Substrate Level phosphorylation occurs during glycolysis... step 6, during the formation of 1,3 bisphosphoglycerate from GAP step 1, during formation of glucose-6-phosphate from glucose Step 3, during formation of Fructose-1,6-Bisphosphate from Fructose-6-Phosphate Step 9 - Formation of Phosphoenolpyruvate from 2-phosphoglycerate QUESTION 7 The amino acid responsible for introducing kinks in DNA helical structure by intercalation is Phenylalanine Ethidium Bromide Tryptophan O Proline QUESTION 8 Most proteins interact with DNA in the form of Head to tail heterodimers Head to tail...
QUESTION 4 The adenylate pool (ATP+ADP+AMP) for two cell types is shown below. Calculate the energy...
QUESTION 4 The adenylate pool (ATP+ADP+AMP) for two cell types is shown below. Calculate the energy charge of each and determine which is the more anabolic cell type. liver cells cancer cells ATP 3.4 mm 1.25 mm ADP 1.3 mm 0.35 mM AMP 0.3 mm 0.12 mm energy charge metabolic state 0.81 0.83 0.85 0.87 0.89 0.91 Less anabolic More anabolic QUESTION 5 Adenylate kinase is a ubiquitous en through B-phosphoryl transfer from aintain short term ATP pools during high...
QUESTION 28 1,3-bisphosphoglycerate is one of the two phosphoryl group donors in the synthesis of ATP during glycolysis, in human erythrocytes, the steady-state concentration of ATP is 2.24 mM ADP IS 0.25 mm, and 3-phosphoglycerate is 0.12 mm. Calculate the concentration of 13. bisphosphoglycerate at 25°C, assuming that the phosphoglycerate kinase reaction) is at equilibrium in the cell. (Standard delta G=-18.9). 5.3E-7M 5.1E-5M 3.4E-6 M QUESTION 30 Why is the glyoxylate cycle critical for the growth and development of young...
3. The reaction in gluconeogenesis that converts 3-phosphoglycerate to 1,3-bisphosphoglycerate is at right. The AGC for this reaction is +18.9 kJ/mol. H-C-OH o HC - H-C-OH H2C 0 ATP ADP P-O 0 3-phosphoglycerate 1,3-bisphosphoglycerate a) What is the concentration of 3-phosphoglycerate under standard state conditions? b) In the hepatocyte, this reaction is near equilibrium. What is the AG in the cell? c) What is the ratio of products-to-reactants for this reaction in the hepatocyte? Assume the temperature is 25°C (298...
5. During step six of glycolysis glyceraldehyde-3-phosphate (G3P) is converted to 1,3- bisphosphoglycerate (1,3-BPG) and NAD+ is converted to NADH. (You can ignore the concentration of protons in the upcoming calculation.) G3P + P + NAD+ = 1,3 - BPG + NADH + H+ In the human erythrocyte, the concentration of G3P is 0.019 mm, the concentration of 1,3-BPG is 0.001 mM, the concentration of P, is 1.0 mm, and the ratio of NAD+ to NADH is 1000 to 1....
Glycolysis activity 1: Metabolic pathway puzzle Try to complete the activity without using the textbook. 1. Slides 4 and 5 show the 10 reactions for glycolysis, but some of the molecules are missing. Draw the missing molecules in the proper place (on the handout). The missing molecules are shown on the next slide, you have to use the clues on the handout and your organic chemistry knowledge to figure out where each molecule belongs. 3. In the red dotted boxes...
SOS 4 & 5
bo V/pid. 2137185-at-content-na-15926494-2/courses/CHEM400,01-FA2018/CHEM400%20F18%2 4. When the glucocorticoid receptor binds to its receptor in the el... a. what is the effect of this binding on the expression of the Annexin I gene? b. what is the effect of this binding on the expression of the CoX-2 gene? c. what is the net effect on inflammation? 5. In step 7 of glycolysis, 1,3-BPG (1,3-bisphosphoglycerate) is converted into 3-PG (3- phosphoglycerate), and ATP is synthesized. The AG for this...
Concentrations of some glycolysis intermediates in the red blood cell (mM): Glucose Glucose-6-P Fructose-6-P Fructose-1,6-BP 1,3-bisphosphoglycerate 0.001 3-phosphoglycerate 5.0 0.083 0.014 0.031 2- phosphoglycerate Phosphoenolpyruvate Pyruvate ATP ADP Pi 0.030 0.023 0.051 1.85 0.14 1.0 0.12 3. Isotopic labeling (incorporating a rare isotope, eg. the radioactive 1C, into a molecule at a defined position) is an important technique for studying metabolism as it enables us to follow individual atoms through a metabolic pathway 2 a. If 4CO2 were bubbled through...
1.
2.
3.
4.
Select all that apply. Identify the reaction(s) of glycolysis inhibited by ATP □ glyceraldehyde-3-phosphate → 1,3-bisphosphoglycerate phosphoenolpyruvate +pyruvate 3-phosphoglycerate ~2-phosphoglycerate 1) fructose-6-phosphate→ fructose-1,6-bisphosphate . glucose glucose-6-phosphate Select all that apply. Alcohol fermentation: consumes ATP as it produces ethanol. O produces carbon dioxide begins as pyruvate is decarboxylated to acetaldehyde in a reaction catalyzed by alcohol dehydrogenase m regenerates NAD requires the enzyme alcohol dehydrogenase, In the figure below, what is the reaction occurring at the location...
Substrate Level phosphorylation occurs during glycolysis... step 6, during the formation of 1,3 bisphosphoglycerate from GAP step 1, during formation of glucose-6-phosphate from glucose Step 3, during formation of Fructose-1,6-Bisphosphate from Fructose-6-Phosphate Step 9 - Formation of Phosphoenolpyruvate from 2-phosphoglycerate QUESTION 7 The amino acid responsible for introducing kinks in DNA helical structure by intercalation is Phenylalanine Ethidium Bromide Tryptophan O Proline QUESTION 8 Most proteins interact with DNA in the form of Head to tail heterodimers Head to tail...
QUESTION 4 The adenylate pool (ATP+ADP+AMP) for two cell types is shown below. Calculate the energy charge of each and determine which is the more anabolic cell type. liver cells cancer cells ATP 3.4 mm 1.25 mm ADP 1.3 mm 0.35 mM AMP 0.3 mm 0.12 mm energy charge metabolic state 0.81 0.83 0.85 0.87 0.89 0.91 Less anabolic More anabolic QUESTION 5 Adenylate kinase is a ubiquitous en through B-phosphoryl transfer from aintain short term ATP pools during high...
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