Homework Answers
Question 12:
A) Beta globin gene is mutated. Beta globin gene
B) Missense mutation (point mutation in which a single nucleotide change results in a codon that codes for a different amino acid)
C) Glutamic acid is changes into Valine. In DNA sequence, The triplet codon for Glutamic acid (i.e. GAG) is point mutated, A is replaced with T (i.e. GAG ---- GTG) and the resulting codon code for Valine instead of Glutamic acid.
D) Sickle cell anemia is the result of a point mutation, a change in just one nucleotide in the gene for hemoglobin. This mutation causes the hemoglobin in red blood cells to distort to a sickle shape when deoxygenated. The sickle-shaped blood cells clog in the capillaries, cutting off circulation.
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12. Answer a few questions about sickle cel What protein is mutated in a person with...
Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the...
Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule. Recall that hemoglobin carries oxygen in your red blood cells. The mutation causes these red blood cells to become stiff & sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of stroke, blindness, damage to the heart & lungs, and other conditions. Analyze...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
please help 6. How can a missense mutation-such as in sickle cell disease-result in a protein...
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
What is protein X and what gene could be mutated to cause these results? Wild type...
What is protein X and what gene could be mutated to cause these results? Wild type Mutant DNA Protein X DNA Protein X Compound Compound Untreated US Protein X is a nuclear hormone receptor. The mutation is in protein X and it no longer binds compound S. Protein X is a nuclear hormone receptor. The mutation is in protein X and increases its affinity for compound Protein X is NFAT. The mutation is in the GPCR that binds compound U...
please answer all parts 25) A few points: Explain how a single nucleotide substitution in the...
please answer all parts
25) A few points: Explain how a single nucleotide substitution in the sequence of a gene can: A) cause a mutation (a single amino acid replacement) in the protein coded by the gene and B) how such a single nucleotide substitution does not necessarily lead to a mutation in the protein (a silent mutation). Be very specific and use real examples for the nucletotides and the resulting amino acid in the protein. You must provide the...
1. Explain how some patients who are homozygous for the sickle-cell allele do not develop sickle-cell...
1. Explain how some patients who are homozygous for the sickle-cell allele do not develop sickle-cell crisis or other symptoms of the disease. Because of a mutation to a regulatory gene, a variant form of the beta subunit is expressed that does not cause sickling of hemoglobin protein. Because of a defective regulatory gene, fetal hemoglobin is expressed in adulthood which compensates for defective adult hemoglobin. Because of an additional mutation to the gene for the beta subunit of hemoglobin,...
Did I answer the mRNA sequences and Amino acid sequences correctly? What types of mutations are...
Did I answer the mRNA sequences
and Amino acid sequences correctly? What types of mutations are
these? How do you do the bottom?
Part 3. Cystic Fibrosis Directions: Cystic Fibrosis is a disorder where the individuals have long and kidney problems. The disorder is caused by a mutation in one of the individual's genes. Complete the boxes below by finding the mRNA and amino acid sequence Compare the moutant DNA strands to the original strand. Circle the mutation in the...
Use the following information to answer the next two questions. Sickle cell anemia is a disease...
Use the following information to answer the next two questions. Sickle cell anemia is a disease that is caused by a mutation in the gene that produces haemoglobin. Hemoglobin carries oxygen in red blood cells. The HbA allele produces normal hemoglobin and the HbS allele produces haemoglobin that sticks together and causes red blood cells to sickle. Heterozygous individuals (HbAHbS) produce both normal and "sickle" hemoglobin so the HbA and HbS alleles are codominant. Heterozygotes do not develop sickle cell...
In plain language, describe what the oxygen-hemoglobin dissociation curve shows. Under normal conditions, the curve can...
In plain language, describe what the oxygen-hemoglobin
dissociation curve shows. Under normal conditions, the curve can
shift to the right and left. A right shift can be induced by
increased temperature and lower pH among other things. Describe
what a right shift means in terms of hemoglobin’s relationship to
oxygen. In your answer, be sure you address what is actually
happening at the level of the protein (hemoglobin is a protein).
Discuss what types of molecular interactions that can cause...
Use the lab manual to answer the following questions in COMPLETE SENTENCES. 1.Read through the introduction....
Use
the lab manual to answer the following questions in COMPLETE
SENTENCES.
1.Read through the introduction. Answer the questions in
between each historical section.
2. Describe tge activity that you ate doung for investygation
3. What does lysis and protease mean?
3. Which disease is describe in investigation 4?
what mutation?
PRE-LAB: LAB EXERCISE 7 Directions: Use the lab manual to answer the following questions in COMPLETE SENTENCES AND IN YOUR OWN WORDS. Use your own handwriting, do NOT type!...
Sickle Cell Anemia Sickle cell anemia is the result of a type of mutation in the gene that codes for part of the hemoglobin molecule. Recall that hemoglobin carries oxygen in your red blood cells. The mutation causes these red blood cells to become stiff & sickle-shaped when they release their oxygen. The sickled cells tend to get stuck in blood vessels, causing pain and increased risk of stroke, blindness, damage to the heart & lungs, and other conditions. Analyze...
Sickle-cell Anemia Study Sickle-cell anemia or Sickle-cell disease, is a hereditary disorder. characterized by aryabnormality in the oxygen-carrying hemoglobin molecule in erythrocytes. Sickle-cell conditions have an autosomal recessive pattern of inheritance from parents. The sickle cell defect is a mutation of a single nucleotide of the hemoglobin B gene, which results in glutamic acid being substituted by a different amino acid at position 6. Hemoglobin with this mutation is referred to as Hbs, as opposed to the normal hemoglobin HbA....
please help
6. How can a missense mutation-such as in sickle cell disease-result in a protein that has an abnormal structure? Some of these mutations are lethal or cause serious disease, such as cystic fibrosis and sickle cell disease. Many of these point mutations that cause genetic disorders occur as a result of errors in DNA replication or crossing over. 7. What will be the consequence if a single base is deleted from the coding region of a gene?
What is protein X and what gene could be mutated to cause these results? Wild type Mutant DNA Protein X DNA Protein X Compound Compound Untreated US Protein X is a nuclear hormone receptor. The mutation is in protein X and it no longer binds compound S. Protein X is a nuclear hormone receptor. The mutation is in protein X and increases its affinity for compound Protein X is NFAT. The mutation is in the GPCR that binds compound U...
please answer all parts
25) A few points: Explain how a single nucleotide substitution in the sequence of a gene can: A) cause a mutation (a single amino acid replacement) in the protein coded by the gene and B) how such a single nucleotide substitution does not necessarily lead to a mutation in the protein (a silent mutation). Be very specific and use real examples for the nucletotides and the resulting amino acid in the protein. You must provide the...
Did I answer the mRNA sequences
and Amino acid sequences correctly? What types of mutations are
these? How do you do the bottom?
Part 3. Cystic Fibrosis Directions: Cystic Fibrosis is a disorder where the individuals have long and kidney problems. The disorder is caused by a mutation in one of the individual's genes. Complete the boxes below by finding the mRNA and amino acid sequence Compare the moutant DNA strands to the original strand. Circle the mutation in the...
In plain language, describe what the oxygen-hemoglobin
dissociation curve shows. Under normal conditions, the curve can
shift to the right and left. A right shift can be induced by
increased temperature and lower pH among other things. Describe
what a right shift means in terms of hemoglobin’s relationship to
oxygen. In your answer, be sure you address what is actually
happening at the level of the protein (hemoglobin is a protein).
Discuss what types of molecular interactions that can cause...
Use
the lab manual to answer the following questions in COMPLETE
SENTENCES.
1.Read through the introduction. Answer the questions in
between each historical section.
2. Describe tge activity that you ate doung for investygation
3. What does lysis and protease mean?
3. Which disease is describe in investigation 4?
what mutation?
PRE-LAB: LAB EXERCISE 7 Directions: Use the lab manual to answer the following questions in COMPLETE SENTENCES AND IN YOUR OWN WORDS. Use your own handwriting, do NOT type!...
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