Question

Which mutation has the most detrimental effect on the organism? Why? wild type--> AUGAUUGUCCCCAAAUAG Mutant 1...

Which mutation has the most detrimental effect on the organism? Why?

wild type--> AUGAUUGUCCCCAAAUAG

Mutant 1 --> AUGAUUCUCCCCAAAUAG

Mutant 2 --> AUGAUUGUCCCCUAAUAG

Mutant 3--> AUGAUGUCCCCAAAUAG

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Answer #1

The amino acid sequence of mRNA is found from the mRNA codon chart.

Please look in the image :

5 с 3 A UU Gug ССС AAA VA wild AU type N-met- ile val - pro- Lys-C CUG ccc AAA Mutant 15% Aug. AUU cuc N- met - ile - Leur pr

Mutant 1 is a mis-sense mutation. There are found single amino acid change. That's why it is not detrimental in nature

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Mutant 2 is a non sense mutation. But mutation is found at the last codon. UAA stops codon is created. The last amino acid is not found.

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Mutant 3 is a frame shift mutation. This leads to change the whole sequence of amino acid in a protein.

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Mutant 3 is more detrimental in nature. Because there found whole amino acid sequence change in the protein as compared to wild type.

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