Are there differences in melanocortin receptor expression on the cell surface?
Are there differences in melanocortin receptor expression on the cell surface?
Homework Answers
Melanocortins are neuropeptides mainly expressed at the hypothalamus and pituitary that exert their effects through binding to a family of five melanocortin receptors (MC1R to MC5R).
- MCRs are involved in diverse cellular functions such as pigmentation, steroidogenesis, energy homeostasis and sexual function.
- The last MCR to be discovered was MC5R; this receptor has a wide peripheral distribution in mammals.
- It has been implicated in the regulation of exocrine glands secretion, muscle fatty acid oxidation and glucose uptake, and adipocyte lipolysis and re-esterification.
- All MCRs belong to the family of G-protein coupled receptors (GPCRs), composed of an extracellular N-terminus, intracellular C-terminus and 7 transmembrane domains connected by intracellular and extracellular loops.
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Are there differences in melanocortin receptor
expression on the cell surface?
Are there differences in total expression of the melanocortin receptor among species?
Are there differences in total expression of the melanocortin receptor among species?
QUESTION 44 Describe the path a cell surface receptor will take when being synthesized (starting at...
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