Question

If an individual lacked functional AID ______________________________. (Select all that apply.)

Group of answer choices

A. there would be a deficiency of B cells and the individual would require a bone marrow transplant to survive

B. the individual’s B cells would produce primarily IgM antibodies

C. the individual’s B cells would not be able to isotype switch from IgM to IgD

D. the individual’s B cells would not be able to mediate isotype switching

Answer 1

Activation-induced cytidine deaminase (AID), lacking will contribute to the deficiency in the Somatic hypermutation and class switching. Hence the B cells produced won't be able change its class of antibody from IgM to other type. This enzyme is produced by the B cell upon antigen exposure and hence the bone marrow deficiency is responsible. Hence the correct answers are:

A. there would be a deficiency of B cells and the individual would require a bone marrow transplant to survive

C. the individual’s B cells would not be able to isotype switch from IgM to IgD

D. the individual’s B cells would not be able to mediate isotype switching