4. Using either diethyl malonate or ethyl acetoacetate, design a synthesis for the following products: a)...
How would you synthesize each of the following from either ethyl acetoacetate or diethyl malonate? Show retrosynthesis and forward synthesis|. a) b)
Propose an efficient and elegant synthesis of each of the following molecules using either diethyl malonate or ethyl acetoacetate as your starting material. You may use any alkyl halide or alcohol as your other sources of carbon, and you may use any reagent you deem necessary. CH3 EN CH₂ HCO CH, Hgc CH, CHA CH₃ -CHS
4. (6 points) What is the condensation product if diethyl malonate is used instead of ethyl acetoacetate? но. но н* heat resorcinol diethyl malonate 1) Is this reaction faster or slower than the reaction with ethyl acetoacetate? 2) Explain why.
8. Give a synthesis of the compound shown starting from either diethyl malonate (DEM) or ethyl acetoacetate (EAA) shown in the box below. Give all reagents necessary. State clearly whether your starting compound is DEM or EAA. You do not need to draw the intermediate steps. 17 pts] Eto Et Hoce DEM ΕΑΑ. 9. Draw the uncharged product of this synthetic sequence. [4 pts] 1. KOH OCH 3. NaOH(aq) excess 10. By how much will the mass of this compound...
The Malonic Acid synthesis is similar to the Acetoacetic Ester synthesis It uses diethyl malonate as the main starting material Draw the structure of diethyl malonate (malonic ester) Diethyl malonate can be hydrolyzed back to malonic acid and if heat is applied after the hydrolysis, will decarboxylate. Draw the mechanism for this transformation starting with malonic acid. Indicate the new C-C bonds in each molecule and then provide the organohalides which were used to synthesize each compound using the malonic...
Synthesis- choose four of these six problems. A fifth may be done for extra credit. A) Starting with ethyl-acetoacetate, prepare B) Starting with diethyl malonate, prepare (C_5H_11)_2 CHCO_2H. C) Using examine synthesis, prepare
Diethyl malonate can be prepared by the following reaction sequence. Draw the structures of each of the missing intermediates in the boxes provided. 4. |сH,сH он. 1. Bry PBr3 OH 2. H2O не На NaCN HSO NC CH CH-OH осH сH, CH2 HQ, heat CH2 HCl OEt Et0 How would you prepare each of the following compounds using either an acetoacetic ester synthesis or a malonic ester synthesis? Show all intermediate structures and all reagents 5. COOH
17 April 2019 Problems te wing molecules using either diethyl malonate or alkyl halide or alcohol as your other sources of ny CH3 2. CH3 HaC CH
Malonic ester (diethyl malonate) is treated successively with sodium ethoxide (1 eq.), ethyl bromide, potassium tert-butoxide, isobutyl chloride, hot aqueous NaOH HCI, and heat. What is the final product? 6-Methylheptanoic acid • 2-Ethyl-3-methylpentanoic acid HE Ethylisobutylmalonic acid 4-Ethyl-2-methylpentanoic acid 2 Ethyl-4-methylpentanoic acid
Propose a synthesis of the following derivative of diethyl malonate using reagents from the choices provided below. (From the choices provided, list the reagent(s) in order that will accomplish this transformation. No more than 4 steps are required. List your answer as a single letter (single-step transformation) or a series of letters (multi-step transformation) with no commas separating them.) Reagents available a. Eto Na g. CH2=CHCH=CHCH,Br b. CH3 CH2Br c. CH3 CH, CH, CH(CH3)Br d. (CH3)2 CHCH, CH,Br e. CH3...