How would you synthesize each of the following from either ethyl acetoacetate or diethyl malonate? Show...
4. Using either diethyl malonate or ethyl acetoacetate, design a synthesis for the following products: a) b)
Propose an efficient and elegant synthesis of each of the following molecules using either diethyl malonate or ethyl acetoacetate as your starting material. You may use any alkyl halide or alcohol as your other sources of carbon, and you may use any reagent you deem necessary. CH3 EN CH₂ HCO CH, Hgc CH, CHA CH₃ -CHS
8. Give a synthesis of the compound shown starting from either diethyl malonate (DEM) or ethyl acetoacetate (EAA) shown in the box below. Give all reagents necessary. State clearly whether your starting compound is DEM or EAA. You do not need to draw the intermediate steps. 17 pts] Eto Et Hoce DEM ΕΑΑ. 9. Draw the uncharged product of this synthetic sequence. [4 pts] 1. KOH OCH 3. NaOH(aq) excess 10. By how much will the mass of this compound...
Diethyl malonate can be prepared by the following reaction sequence. Draw the structures of each of the missing intermediates in the boxes provided. 4. |сH,сH он. 1. Bry PBr3 OH 2. H2O не На NaCN HSO NC CH CH-OH осH сH, CH2 HQ, heat CH2 HCl OEt Et0 How would you prepare each of the following compounds using either an acetoacetic ester synthesis or a malonic ester synthesis? Show all intermediate structures and all reagents 5. COOH
(9) 8. Show how you would accomplish the following multistep synthesis: Synthesize the insect repellent N,N-diethyl-n-toluamide from m-toluic acid. Use compounds with no more than 5 carbons as your other reagents. NC CH 3 2 from
Problem #3 Show how you would synthesize ethyl benzoate in good yield starting from benzene. You may use any other reagent necessary
how to synthesize the compund from the two starting materials this is the retrosynthesis i got and i just wanted to know if it was possible CI OH Eto OEt diethyl malonate 1,6-dichlorohexane cyclohexylmethanol b r alcohol OH OEt ethyl 3-oxobutanoate 1,6-dichlorohexane 1-cyclohexylethan-1-01 ls methyl Herone Ero i i -OEr & an wa 2 eq. NaOet Erol Ero og HO-130 "OET > HO H2O OM neat - CO2 Li ATMA colt Ho ой
0.5 pts Question 4 (10 points) Show how you would synthesize the following aromatic compound from benzene and any other reacents necessary. Hint: Retrosynthesis. P .NO2 u h CH3 The reaction code in the box is:
sbow how you woukd synthesize each of the following compounds from benzene (a) Show how you would synthesize each of the following compounds from benzene. Br (b) (c) (d) NHA Br. Br. (e) HN NH2
Please show the entire mechanism for this problem, thank you! 46) Malonic ester (diethyl malonate) is treated successively with sodium ethoxide (1 eq.), 1- bromopentane, potassium tert-butoxide, iodomethane, hot aqueous NaOH, HCl, and heat. What is the final product? a) 2-Methylheptanoic acid b) 3-Methylhexanoic acid c) 3-Methylpentanoic acid d) 2-Methylpentanoic acid e) Ethyl 2-methylheptanoate 47) What would be the major product of the following reaction sequence? 1. BH PCC 1. LDA (-78°C) 2. H,02, OH CH,C12 2. CH3CH,Br ఎంత a)...