Question

This link below will lead you to the article that must be read in order to answer those questions.

http://www.cell.com/cell-reports/fulltext/S2211-1247(13)00397-5

Based on the article linked above, answer the following questions.

Discussion: This portion of your presentation should include the following:

1. A brief summary of the paper’s findings (these can simply be listed as bullets)

2. A brief discussion of how this study contributes to our understanding of apoptosis and the particular disease of study.

a. Go back to the magazine article title and story. How does the author’s work fit in with the “Big Picture”?

3. Brief critique of the study

a. Which experimental finding(s) did you find most convincing/compelling and why?

b. Which experimental finding(s) did you find the least convincing/compelling and why?

4. Future directions for the study

Please list at least two. If the authors do not propose two future directions, please propose your own.

Answer 1

1) The paper describes about the role of receptor interacting protein -3 (RIP-3) in hepatic carcinogenesis. The brief summary of the papers description is listed below,

• RIP3- and Caspase-8-dependent pathways are activated in chronically inflamed livers

• RIP3 limits compensatory proliferation via a pathway involving Caspase-8 and JNK
• RIP3 impedes Caspase-8-dependent chromosomal aberrations and inhibits tumor growth
• RIP3 promotes jaundice and cholestasis by limiting biliary ductular reactions

Please post other questions separately.