Question

Significant to complete loss of protein function vs partial to negligible loss of protein function

Frameshift mutation in the middle ofmperfect excision of a transposon that leaves a 10bp footprint in the first exon Deletion of 2 base pairs just downstream of the start codon Perfect excision of a transposon a gene Missense mutation in a region of the gene that is required for proper folding/function of the protein Silent mutation in a region of a gene that contains a conserved domain Deletion of 3 base pairs just upstream of the stop codon Nonsense mutation in the third of fifteen exons Replication slippage that deletes 10bp from the second intron Transversion in the first intron Deletion of the promoter Significant to Complete Loss of Protein Function Partial to Negligible Loss of Protein Function

Answer 1

Significant to Complete Loss of Protein Function:

• Frameshift mutation in the middle of a gene.
• Imperfect excision of a transposon that leaves a 10bp footprint in the first exon.
• Deletion of 2 base pairs just downstream of the start codon.
• Missense mutation in a region of the gene that is required for proper folding/function of the protein.
• Nonsense mutation in the third of fifteen exons.
• Deletion of the promoter.

Partial to Negligible Loss of Protein Function:

• Perfect excision of a transposon.
• Silent mutation in a region of a gene that contains a conserved domain.
• Deletion of 3 base pairs just upstream of the stop codon.
• Replication slippage that deletes 10bp from the second intron.
• Transversion in the first intron.