Question

Identify diabetes as a specific disease encountered in your clinical practice or personal life. Can your patient's understanding of DNA/RNA replication, transcription, and translation affect the management of the disease? Explain. Support your rationale with a minimum of two scholarly sources.

Answer 1

Metabolic memory is defined as the persistence of diabetic complication even after gycemic control is pharmacologically achevied.using a zebrafish diabetic model that induces a MM state,previously reported that in this model ,tissue dysfunction was of a heritable nature based on cell prolification studied in limb tissue and this correlated with epigenetic DNA methylation changes that paralleled alternations in gene ,expression .in the current study,control ,DM and MM excised. Fin tissue were further analyzed by MeDIP sequencing and microarray techniques.analysis of data found that genes of The DNA replication metabolism process group of the apex1,mcm2,mcm4,orc3,ligI were altered in the DM state this molecular changes continued into MM .DNA methylation changes could be as far as 6-13 kb uostream of the transcription start site of these genes suggesting potential higher level of epigenetic control .in conclusion DNA methylation changes in membre of of the DNA replication /repair process group best explain the heritable nature of cell proliferation impairment found in the zebrafish DM /MM model. These results are consistent with human diabietic engenetic studied and provide one explaination for the persistence of long term tissue complications as seen in diabetes.translation has emerged as an important site of regulation of protein expression during development and disease.