how thymidine relieve the inhibition of the TTP biosynthetic pathway? and why FUdR inhibitor will be...
how thymidine relieve the inhibition of the TTP
biosynthetic pathway?
and why FUdR inhibitor will be detected in S-phase?
thank you
Homework Answers
Thymidine relieves the inhibition of the TTP (Thymidine triphosphate) biosynthetic pathway. Thymidine salvage by Thymidine kinase 2 enzyme is necessary for the TTP biosynthetic pathway. TTP is generated from thymidine by the action of thymidine kinase, thymidylate kinase, and nucleoside diphosphate kinase. Thymidine reacts with ATP to give thymidine monophosphate and ADP by help of enzyme Thymidine kinase. Thymidine monophosphate is phosphorylated to thymidine diphosphate by the help of enzyme thymidylate kinase. Thymidine diphosphate is further phosphorylated to thymidine triphosphate by the help of enzyme nucleoside diphosphate kinase. This is how thymidine relieves the inhibition of the TTP biosynthetic pathway.
FUdR inhibitor will be detected in S-phase because FUdR results in the cell cycle arrest at the S-phase. FUdR acts as an inhibitor of DNA replication by binding to thymidylate synthase during the S-phase.
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