You are investigating signaling pathways involved in the control of cell cycle. Why is SDS-PAGE well...
You are investigating signaling pathways involved in the control of cell cycle. Why is SDS-PAGE well suited in studies of cyclin modification but not in studies of retinoblastoma pRb phosphorylation?
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You are investigating signaling pathways involved in the control
of cell cycle. Why is SDS-PAGE well...
5.DISEASE AND PATHWAYS: Most drugs target proteins involved in signaling pathways in the cell. Describe two examples by...
5.DISEASE AND PATHWAYS: Most drugs target proteins involved in signaling pathways in the cell. Describe two examples by which a protein can be chemically altered and thereby act as a logic switch in a signaling pathway in the cell. 6.MOLECULAR DRUG DOCKING: Why is molecular docking (e.g. autodock vina) take less time to run than molecular dynamics? What aspect of molecular reality regarding the target protein is sacrificed during simulation to obtain computational speed?
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add...
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add an upstream signal to a cell culture to activate the M-cyclin. Result 1 - GFP fluorescence intensity increases. Experiment 2 - You genetically tag adenylyl cyclase with RFP. You add an upstream signal to a cell culture to activate adenylyl cyclase. Result 2 - There is no change...
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add...
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add an upstream signal to a cell culture to activate the M-cyclin. Result 1 - GFP fluorescence intensity increases. Experiment 2- You genetically tag adenylyl cyclase with RFP. You add an upstreanm signal to a cell culture to activate adenylyl cyclase. Result 2 There is no change in the...
You are a studying the progression of cells through the cell cycle. You are particularly interested...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcia...
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make...
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
Consider a spontaneous mutation in the gene HER2, a tumor suppressor involved in cell cycle control...
Consider a spontaneous mutation in the gene HER2, a tumor suppressor involved in cell cycle control Mutations happen at a rate of about 1 error per 109 bases per generation. A spontaneous deleterious mutation must occur in HER2 specifically, and not in another gene. The likelihood that a spontaneous mutation is deleterious and could lead to cancer depends on the number of mutable bases in HER2, the fraction of bases that will affect the function of HER2, and that both...
The Jounal of Immunol nes of the National Academy of Sciences USA 89. 6550-6554. 01992, by permis...
explain figure 2 please on the third page
The Jounal of Immunol nes of the National Academy of Sciences USA 89. 6550-6554. 01992, by permision of Proc. Natl. Acad. Sci. USA Vol. 89, pp. 6550-63554, July 1992 Immunolog A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells RANDOLPH J. NOELLEć—¶, MEENAKSHI ROY.. DAVID M. SHEPHERD., IVAN STAMENKOVICt JEFFREY A. LEDBETTER, AND ALEJANDRO ARUFFo Departmend Microbiology. Dartmouth Medical School One...
need some assistance with this. thank you very much 1. Free radicals are __________ . (A)...
need some assistance with this. thank you very much 1. Free radicals are __________ . (A) molecules that have lost an electron (C) molecules with extra neutrons (B) escaped political prisoners (D) produced by vitamins 2. The chromosomal location of the APC gene was originally identified by finding a region of the genome that was _________ in patients with colorectal cancer. (A) deleted (B) rearranged (C) normal (D) unclear 3. The National Health Service of the United Kingdom (Britain) has...
need some assistance with this please. thank you very much 1. Free radicals are __________ ....
need some assistance with this please. thank you very much 1. Free radicals are __________ . (A) molecules that have lost an electron (C) molecules with extra neutrons (B) escaped political prisoners (D) produced by vitamins 2. The chromosomal location of the APC gene was originally identified by finding a region of the genome that was _________ in patients with colorectal cancer. (A) deleted (B) rearranged (C) normal (D) unclear 3. The National Health Service of the United Kingdom (Britain)...
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add an upstream signal to a cell culture to activate the M-cyclin. Result 1 - GFP fluorescence intensity increases. Experiment 2 - You genetically tag adenylyl cyclase with RFP. You add an upstream signal to a cell culture to activate adenylyl cyclase. Result 2 - There is no change...
7. You perform the following microscopy experiments to measure the signaling output of two pathways and observe the following results. Experiment 1 - You genetically tag an M-cyclin with GFP. You add an upstream signal to a cell culture to activate the M-cyclin. Result 1 - GFP fluorescence intensity increases. Experiment 2- You genetically tag adenylyl cyclase with RFP. You add an upstreanm signal to a cell culture to activate adenylyl cyclase. Result 2 There is no change in the...
You are a studying the progression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcin B/CDK2. Given...
1) You are a studying the prog ression of cells through the cell cycle. You are particularly interested in the role of the APC, which in a ubiquitin E3 ligase, in the control of the metaphase cyclin (cyclin B) and the timing of events. To look at this you start by synchronizing your cells in G1 and examining the levels of Cyclin B over time. The APC usually works on cyclin B during anaphase. RBX57 is a substrate for Cylcia...
Cancer cells often lack normal DNA damage response and cell-cycle control mechanisms. Why does this make them more susceptible to DNA-damaging chemotherapies? O Cancer cells will arrest in the cycle and will not grow further O Cancer cells with activating mutations in Ras will amplify the damage through the Ras signaling pathway Cancer cells might ignore the normal mechanisms that halt the cell cycle in response to damage, and subsequent division with damage leads to death, O Cancer cells have...
Consider a spontaneous mutation in the gene HER2, a tumor suppressor involved in cell cycle control Mutations happen at a rate of about 1 error per 109 bases per generation. A spontaneous deleterious mutation must occur in HER2 specifically, and not in another gene. The likelihood that a spontaneous mutation is deleterious and could lead to cancer depends on the number of mutable bases in HER2, the fraction of bases that will affect the function of HER2, and that both...
explain figure 2 please on the third page
The Jounal of Immunol nes of the National Academy of Sciences USA 89. 6550-6554. 01992, by permision of Proc. Natl. Acad. Sci. USA Vol. 89, pp. 6550-63554, July 1992 Immunolog A 39-kDa protein on activated helper T cells binds CD40 and transduces the signal for cognate activation of B cells RANDOLPH J. NOELLEć—¶, MEENAKSHI ROY.. DAVID M. SHEPHERD., IVAN STAMENKOVICt JEFFREY A. LEDBETTER, AND ALEJANDRO ARUFFo Departmend Microbiology. Dartmouth Medical School One...
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