Question

"Peaches," is an 81.4 lb., FS 12 yr old Golden Retriever diagnosed with lymphoma. Her owners have elected to try chemotherapy BEES sellesel The veterinarian decides to use the following protocol for lymphoma: 28. Calculate the dose for L-Asparaginase (10,000 IU in a 10 mL vial). 29. How many vials will you need of L-Asparaginase?

Veternarian Nursing/<edical Mathamatics. Tutoring help. Thanks

needing help with the questions that are persented on the table. Not understaning information. It is a veternarian nursing/ math class. That is the best way I can subscribe it.

iI can resubmit if neccesary if you can not read the chart

Answer 1

Please note that only 4 subparts of the question is answered.

Weight of the dog in kg = 81.4 lb x 0.45 = 36.63 kg (since 1 lb = 0.45 kg))

36.63 kg body weight approximately corresponds to 1.11 m2 body surface area of dog ( according to above conversion chart)

28)

The dose of L-Asparginase = 15,000 IU x 1.11 m2 = 16,650 IU sc ( since 15,000 IU is needed per m2)

since 10,000 IU drug is present in 10 mL solution ( 1 vial )

therefore, 16,650 IU will be present in 16,650 / (10,000 / 10) = 16.65 mL of solution IV

29)

Number of vials of L-Asparginase needed = 16.65mL / 10mL = 1.665 vials or 1 vial and 6.65 mL (since 1 vial contains 10 mL )

30)

Dose of Vincristine = 0.6 mg x 1.11 m2 = 0.666 mg IV ( since 0.6 mg drug is needed per m2 )

Since 1 mg drug is present in 1 mL solution

therefore,

0.666 mg drug will be present in 1 x 0.666 = 0.666 mL of solution IV = required dose

31)

Dose of Doxorubicin = 30 mg x 1.11 m2 = 33.3 mg IV ( since 30 mg drug is needed per m2 )

Since 2 mg drug is present in 1 mL solution

therefore,

33.3 mg drug will be present in 33.3 / 2 = 16.65 mL of solution IV = required dose