Insulin signalling acts through an insulin receptor, which is a receptor tyrosine kinase (TRUE OR FALSE?)
Insulin signalling acts through an insulin receptor, which is a receptor tyrosine kinase (TRUE OR FALSE?)
Homework Answers
Answer : The given statement with respect to insulin receptor is TRUE. Binding of insulin to its receptor which has a tyrosine kinase activates phosphorylates many proteins on their tyrosine residues activating them which in turn leads to such physiological changes such as stimulating the uptake of glucose by liver, skeletal muscle and fat tissue and by inhibiting glycogenolysis and gluconeogenesis.
Insulin is a peptide hormone produced by the beta-cells of the islets of Langerhans in response to elevated blood glucose level. Insulin is a hypoglycemic hormone that lowers blood glucose level through various means.
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Insulin signalling acts through an insulin receptor, which is a
receptor tyrosine kinase (TRUE OR FALSE?)
The insulin receptor is an example of a: A. GPCR. B. JAK-STAT receptor. C. receptor tyrosine...
The insulin receptor is an example of a: A. GPCR. B. JAK-STAT receptor. C. receptor tyrosine kinase. D. All of the above. E. A and B.
Choose one out of paracrine signalling, endocrine signalling, autocrine signalling and direct signalling and describe briefly...
Choose one out of paracrine signalling, endocrine signalling, autocrine signalling and direct signalling and describe briefly the process by which this occurs. Pick a representative signal molecule from the pathway you have chosen and indicate its function, the type of cell in which it is made and the specific manner in which it acts as a signalling molecule, including the receptor that it binds to. For example if you chose the endocrine signalling pathway you could consider looking at a...
Choose one out of paracrine signalling, endocrine signalling, autocrine signalling and direct signalling and describe briefly...
Choose one out of paracrine signalling, endocrine signalling, autocrine signalling and direct signalling and describe briefly the process by which this occurs. Pick a representative signal molecule from the pathway you have chosen and indicate its function, the type of cell in which it is made and the specific manner in which it acts as a signalling molecule, including the receptor that it binds to. (For example if you chose the endocrine signalling pathway you could consider looking at a...
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine...
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine kinase activity III. possesses serine/threonine phosphatase activity IV. interacts with proteins such as IRS-1 I, IV I, III II, IV Oll only I, II, III
Which of the following events normally activates a receptor tyrosine kinase GTP hydrolysis by the protein...
Which of the following events normally activates a receptor tyrosine kinase GTP hydrolysis by the protein Dimerization and phosphorylation Activation of an upstream GTPase-activating protein Phosphorylation of a bound GDP molecule by an upstream phosphorylase
Which one of the following statements is false? a. Many growth factor receptors are tyrosine kinases....
Which one of the following statements is false? a. Many growth factor receptors are tyrosine kinases. b. SH2 is an example of a protein domain that has high affinity binding for phosphorylated EGFR. c. Raf initiates a serine/threonine kinase cascade. d. Raf is activated by the kinase activity of RAS. Which one of the following statements is true? a. Retroviruses are a major cause of human cancers. b. Proto-oncogenes are altered forms of normal genes. c. Oncogenic activation of receptor...
Explain the difference between amplification of signal by a tyrosine receptor kinase and a GPCR. Explain...
Explain the difference between amplification of signal by a tyrosine receptor kinase and a GPCR. Explain what would happen if you increased expression of a phosphatase or phosphodiesterase in each situation respectively.
helppp Section: 12.3 GPCRS in Vision, Olfaction, and Gustation Section 12.4 21) Receptor tyrosine kinases: are...
helppp
Section: 12.3 GPCRS in Vision, Olfaction, and Gustation Section 12.4 21) Receptor tyrosine kinases: are dimers. e. f. do not regulate gene expression. g. engage in extensive cross talk with other signal transduction systems. h. bind insulin. Section: 12.4 Receptor Tyrosine Kinases Section 12.5 22) Protein kinase G: is activated by GMP. e. is a tyrosine kinase. is stimulated by sildenafil (Viagra). f. g. activates ion pumps in cardiac tiss h. Section: 12.5 Receptor Guanylyl Cyclases, CGMP, and Protein...
You are interested in determining the function of a newly identified receptor tyrosine kinase (RTK) in...
You are interested in determining the function of a newly identified receptor tyrosine kinase (RTK) in cultured cells. What specific method could you utilize to determine the receptor’s function? Provide a brief description of how this method works.
Which of the following statements concerning signal transduction by the insulin receptor is NOT correct? A....
Which of the following statements concerning signal transduction by the insulin receptor is NOT correct? A. The insulin receptor substrate protein IRS-1 in its phosphorylated form activates other proteins. B. The pathway for insulin-stimulated transcription of specific genes involves the protein Ras. C. The insulin receptor phosphorylates itself in the activation process. D. Insulin stimulation of the insulin receptor initiates a cascade of events causing activation of glycogen synthase. E. The receptor protein kinase activity is specific for serine residues...
Insulin binds to a receptor that_ I. is coupled to a G protein II. possesses tyrosine kinase activity III. possesses serine/threonine phosphatase activity IV. interacts with proteins such as IRS-1 I, IV I, III II, IV Oll only I, II, III
Explain the difference between amplification of signal by a tyrosine receptor kinase and a GPCR. Explain what would happen if you increased expression of a phosphatase or phosphodiesterase in each situation respectively.
helppp
Section: 12.3 GPCRS in Vision, Olfaction, and Gustation Section 12.4 21) Receptor tyrosine kinases: are dimers. e. f. do not regulate gene expression. g. engage in extensive cross talk with other signal transduction systems. h. bind insulin. Section: 12.4 Receptor Tyrosine Kinases Section 12.5 22) Protein kinase G: is activated by GMP. e. is a tyrosine kinase. is stimulated by sildenafil (Viagra). f. g. activates ion pumps in cardiac tiss h. Section: 12.5 Receptor Guanylyl Cyclases, CGMP, and Protein...
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