Clinical pharmacokinetics or pharmacokinetics is a branch of
pharmacology which is dedicated to determine the fate of substances
that are administered within our body. Pharmacokinetics is also
abbreviated as PK. The substance whose fate is being studied is
called a xenobiotic and those include pharmaceutical drugs,
pesticides, cosmetic ingredients etc. Pharmacokinetics can also be
called as the organisms effect on the drug in terms of its
metabolism to excretion.
The pharmacokinetic properties of any particular chemical that is
being taken , depends upon the route of administration of that
particular drug, similarly, its adsoption also varies.
After a drug enters into the body, there is an abbreviation that
helps with the whole course of the drug inside the body -
LADME.
?L- Liberation ( release of the drug from the formulation
form)
A- Adsorption ( The substance entering the blood circulation)
D- Distribution ( Dissemination of the substance , throughout the
body fluids)
M- Metabolism ( Breakdown of the parent compound into the daughter
metabolite)
E- Excretion (Removal of the substance from the body)
Clinical pharmacokinetics can be defined as -
?Clinical pharmacokinetics (arising from the clinical use of
population pharmacokinetics) is the direct application to a
therapeutic situation of knowledge regarding a drug’s
pharmacokinetics and the characteristics of a population that a
patient belongs to (or can be ascribed to).?
?Clinical monitoring is caried out by measuring he plasma
concentration of the drug at various intervals in order to keep a
check on the maximum and the threapeutic levels of the drug. Such
data obtained from studying the plasma concentrations is more
relialable and thus is used more efficiently. The following can be
estimated by clinically studying the plasma concentration:
1) Narrow therapeutic range
?2) High toxicity
3) HIgh risk to life
this can be studied from the graph below :
Write a clinical pharmacokinetics note for the chart detailing your plan of action and rationale.
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i need to write a old chart soap note for NP
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