Name four factors (bonds or other forces) that contribute to stabilizing the native structure of a protein, and describe one condition or reagent that interferes with each type of stabilizing force.
Among forces that stabilize native protein structures are:-
(a) Disulfide bonds
(b) Hydrogen bonds
(c) Hydrophobic interactions
(d) Ionic interactions
Name four factors (bonds or other forces) that contribute to stabilizing the native structure of a...
4. NAME four factors (bonds or other forces) that contribute to stabilizing the native structure of a protein, and DESCRIBE HOW (be specific) one condition for reagent) interferes with each type of stabilizing force. Factor #1: Factor #2: Factor #3: Factor #4:
Tissue factor (TF) contains four cysteine residues that form two disulfide bonds in the native structure of TF. Suppose TF is reduced and unfolded in urea. If the reduced unfolded protein were oxidized prior to the removal of the urea, what fraction of the resulting mixture would you expect to possess native disulfide bonds? Express your answer using three significant figures.
6.) Provide short answers for the questions about protein structure below: a.) True or False, amino acid sequence defines the native structure of protein. b.) What is the main type of bonding responsible for stabilizing the secondary structure of proteins? c.) Briefly discuss the thermodynamics of protein folding into its native 3D structure. Is this process enthalpy driven or entropy driven? d.) Give an example of 2 major secondary structural motifs found in polypeptides. Do any of these motifs appear...
Name and describe four functional properties of the Bcr-Abl fusion protein that contribute to disease progression in CML. Also describe whether these would be gain of function or loss of function mutations with respect to normal Abl kinase activity. Please bullet point your response for ease of grading.
Describe each of the factors in Porter’s Five Forces Model. Summarize the four strategies of Porter’s model of configuration and coordination. What are Porter’s three generic strategies and how are they related to global strategy?
Answer the following questions please: 1) What factors contribute to tertiary structure stability? Give specific examples of the bonds involved, and which one is most important. 2) Define leucine zipper, helix-turn-helix, helix-loop-helix, and zinc finger, and explain why each is stable. 3) What is alpha-helix supercoiling, and why is it so favorable? 4) Why are quaternary structures so important to cell function? 5) Define the following domains: SH2, SH3, Bromo, Chromo, PTB, SNARE, EF-Hand?
e four major attractive forces between particies are ionic bonds, dipole-dipole attractions. hydrogen bonds, and dispersion forces. Consider the compound ow, and classify each by its predominant attractive or intermolecular foroe among atoms or molecules of the same type. ag each item to the appropriate bin. Hints Reset Help MgF, HBr N2 tonic Dispersion
7 Marks The structure of cytosine, one of the four is one of the four main bases found in DNA is shown below. Assign the bonding geometry around each numbered atom in cytosine. 3 HC6 HC NH2 Bonding geometry Atom NI C2 N3 Identify the strongest type of intermolecular forces present in the following four compounds and using this information explain the order of the melting points Melting point (C) -220 Strongest Intermolecular force Species F2 -129 NF3 -87 HBr...
4. (a) Name the four known forces in nature. For each force state the kind of particles the force acts upon, what the approximate range of the force is, and what the field quanta are that mediate the force (4 marks) Briefly explain what is meant by anti-particles and why they are relevant in particle physics (b) (2 marks) Determine whether each of the following decays is allowed. If a decay is allowed determine the interaction involved. If it is...
20 Marks) Question 3 a) The structure of proteins is described at four levels: primary, secondary, tertiary and quaternary Briefly explain what is referred to by each of these terms. Why are these distinctions useful? [5 marks] b) Each level of protein structure is stabilised by chemical bonds and interactions: List the bonds and/or effects primarily responsible for stabilising each level of structure. [5 marks] c) The illustration below shows a molecule of haemoglobin. Describe TWO (2) aspects of haemoglobin...