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Name four factors (bonds or other forces) that contribute to stabilizing the native structure of a...

Name four factors (bonds or other forces) that contribute to stabilizing the native structure of a protein, and describe one condition or reagent that interferes with each type of stabilizing force.

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Answer #1

Among forces that stabilize native protein structures are:-

(a) Disulfide bonds

(b) Hydrogen bonds

(c) Hydrophobic interactions

(d) Ionic interactions

  • Mercaptoethanol interferes with disulfide bonds.
  • Extreme pH hampers hydrogen bonds.
  • Detergent and urea interfere with hydrophobic interactions.
  • Alterations in pH or ionic strength obstructs ionic interactions.

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