Imagine that a scientist mixes bromoethane and potassium iodide in methanol. What type of reaction is...
Question 28 1 pts Imagine that a scientist mixes bromoethane and sodium tert-butoxide in 2-methyl-2-propanol. What type of reaction is likely to predominate? Remember to consider the type of alkyl halide that is involved, and remember also to consider whether the anion will act predominantly as a base or as a nucleophile or as both a base and a nucleophile. If the latter, consider the figure below to guide your decision. Finally, remember to consider the Apka rule, as it...
5. REACTIONS (30PTS, 6PT EA): For the following reactions indicate what substituted alkyl halide sol are provided and choose indicated reaction conditions, 2) then provide the major product or indicate dicate what substituted alkyl halide, solvent, and nucleopa cmajor product or indicate NO REACTION Closed Inuci NaOEt alkoi halide: 1.1.3 Salt Polar Proti Polar Agrote Noclegile strong wak Br EtOH Of Shade one — SI E2 S 2 EI Circle one cach alky balide 1º, 2º, 3º Solvent Polar Prote/Polar...
strong nucleophile weak base strong bulky base strong nucleophile strong base Promote SN2/E2 weak nucleophile weak base Promote SN1/E1 Promote SN2 Promote E2 CH Br HS NCT HO CHO CHÚCHO NaNO NaOH NOME Noe HOORS Conjugate acids have pka 16-18 Conjugate acids Recall, you make hydroxide have pka 11 or alkoxide ons from the corresponding alcohol or water and Nat CH,OH (MOH) HO CH,CH,OH (EXOH) | HC-Ć-o to CH tert-BUOK NOCH KOHBU NEOBU The structures above are all ways of...
Consider a reaction with a 3° leaving group and a strong nucleophile/bad base. What reaction pathway will prevall (SN1, SN2, E1, or E2)? Explain your reasoning.
52.Which are the characteristics and factors that reactions? SN1: 3'alcehels,a altehels E3: laus factors that influence SN2, SN1, E2, E1, and ElcB s should be the major product and machanism of he reaction bertween a secondary alyl halide and an alkoxide? ow can one determine whether an alkyl halide wil roduce a single alkene upon elimination with strong base? tween a tertiary alkyl halide and water? 55.What is the mechanism of the reaction be 56. What change could be made...
2. Predict the product(s) of each of the reaction conditions below. Specify the substrate type (primary, secondary, or tertiary alkyl halide), nucleophile (strong or poor), and the solvent type (protic or aptrotic). Specify the type of reaction mechanism (SN1 or SN2), show the curved arrow mechanism and draw the products as 3D structures to illustrate stereochemistry. Predict the product(s) of each of the reaction conditions below. Specify the substrate type (1º, 2º, or 3 alkyl halide). mucleophile (strong or poor),...
Please, make the answer clear and reable. BrEtOH a OEt Hace H2C Alkyl halides undergo nucleophilic substitution and elimination reactions. When the kinetics of the reaction are measured, if the rate of the reaction is found to be dependent only upon the concentration of the alkyl halide the reaction is first order. The substitution reaction is thus termed ction is termed E1. These reactions are unimolecular and occur in two steps. The first step is rate-limiting and involves the loss...
Indicate which reaction type is favored for each substrate (Questions 19-21) acidic 19. R,CX - solution Each term may be used more than once or not at all. a. E1 Nu b. Sn1 20. RCH,X c. E2 d. SN2 strong 21. R,CHX base Consider the pair of reactions below to answer the following (Questions 22-25) KI 1 + KBr Reaction des de Acetone Reaction A
multiple choice questions! 11. What type of reaction would you predict the following to undergo? Ans. li + NH3 CH3CN ► ? (A) SN1 (B) E1 (C) E2 (D) SN2 12. Which of the following factors will NOT promote an SN1 reaction? Ans. (A) a polar, protic solvent (B) a 3º substrate (C) a strong nucleophile (D) a good leaving group 13. Which one of the following compounds can show cis/trans- isomerism? Ans. (A) 1,1-dimethylcyclopentane (B) 1-ethyl-2-methylcyclobutane (C) 1,1,4-trimethylcyclohexane (D)...
Consider the SN2 reaction of butyl bromide with hydroxide ion , Assuming no other changes, what effect on the reaction rate would result from simultaneously doubling the concentrations of both butyl bromide and hydroxyl ion No effect (B)It would double the rate (C)it would increase the rate six times (D) It would increase the rate four times. 2. Which alky halide would you expect to undergo SN1 hydrolysis most rapidly? (A) (CH3)3C-I (B) (CH3)3C-Br (C) (CH3)3C-Cl (D) (CH3)3C-F 3....