5. REACTIONS (30PTS, 6PT EA): For the following reactions indicate what substituted alkyl halide sol are...
(3 pt) For the following reactions: a) Label the substrate (1°, 2°, 3°), reagent (Good/Poor Nu, Strong/Weak Base) and solvent (protic, aprotic). b) Determine what mechanism will predominate (SN1, SN2, E1, or E2). c) Draw the product(s) you would expect to form, paying attention to regioselectivity and stereoselectivity. 4. (3 pt) For the following reactions: a) Label the substrate (1º, 2º, 3º), reagent (Good/Poor Nu, Strong/Weak Base) and solvent (protic, aprotic). b) Determine what mechanism will predominate (SN1, SN2, E1,...
2. (1.5 pts) Label the following reagents as Good or Poor Nucleophiles AND as Strong or Weak Bases. OK Na SH 3. (1.5 pt) Predict the productts) of the following reactions, if there are multiple products indicate which, if any, is the major product. Be sure to clearly mark the stereochemistry of chiral carbon atoms and draw multiple products if there is more than one stereoisomer that forms. HCI MeOH H2SO H2 Pd/BaSO4 quinoline 4. (3 pt) For the following...
Compare and contrast SN1, SN2, E1 and E2 reactions. What are some obvious similarities and differences between each reaction pathway? What are the requirements for each reaction to work? Discuss why SN2 is in direct competition with E2 while SN1 is in direct competition with the E1 reaction pathway. What is the rate expression for each? Which reactions are concerted? Which reactions are step-wise? Which reactions are stereospecific and what is the stereospecificity of each that are? How do the...
17. Which of the following statements is true? A. An Sw1 reaction always proceeds faster than an S2 reaction. B. An Sw2 reaction is not stereospecific C. Good alkyl halide substrates for an E1 reaction are also good for an E2 reaction. D. Increasing the alkyl halide concentration enhances the reaction rate of an Sw1 reaction but not that of an E2 reaction. 18. For the following reaction, what happens to the reaction rate if the concentration of NaN, is...
Please, make the answer clear and reable. BrEtOH a OEt Hace H2C Alkyl halides undergo nucleophilic substitution and elimination reactions. When the kinetics of the reaction are measured, if the rate of the reaction is found to be dependent only upon the concentration of the alkyl halide the reaction is first order. The substitution reaction is thus termed ction is termed E1. These reactions are unimolecular and occur in two steps. The first step is rate-limiting and involves the loss...
Substitution Problems I. In each of the problems below, label the alkyl halide as primary, secondary, or tertiary, Label the nucleophile as strong or weak. Decide whether an S2 or an Sol reaction occurs. Alter, show the mechanism and product or products. Indicate stereochemistry where appropriate. a. Reaction of 1-bromopropane and sodium methoxide in methanol + Na CH₂ CH OH b. Reaction of 2-bromopropane in ethanol Br + CH.CH, OH - c. Reaction of (R) 3-chloro-3-methylheptane in acetic acid CH3...
Consider the SN2 reaction of butyl bromide with hydroxide ion , Assuming no other changes, what effect on the reaction rate would result from simultaneously doubling the concentrations of both butyl bromide and hydroxyl ion No effect (B)It would double the rate (C)it would increase the rate six times (D) It would increase the rate four times. 2. Which alky halide would you expect to undergo SN1 hydrolysis most rapidly? (A) (CH3)3C-I (B) (CH3)3C-Br (C) (CH3)3C-Cl (D) (CH3)3C-F 3....
_1. An alkyl halide which might be expected to undergo rearrangement under Snl or E1 conditions is: HZC Br CH3 A. 1 B. | F—CH,BH C. CH3-C-CH-CH, CHz CH3 D. CH3 CH3-C-CH2CH2-Br CH3 E. A Br 2. Your task is to convert 2-chloropentane into 1-pentene. Which reagents would you choose? a) NaOH/H20 b) KOH/CH3OH c) CH3ONa/CH3OH d) CH3CH2ONa/CH3CH2OH e) (CH3)3COK/(CH3)3COH 3. Circle the reaction below which is faster in polar protic solvents. OH,H,O A. CH,CH,CH,Br- CH,CH,CH,OH + Br or SH.RSH...