Question

Explain ionotropic and metabotropic signaling in your own words, both the similarities and differences in these two different routes of post-synaptic signaling.

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Answer 1

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9 I on otropic signaling & In this type of signaling ionotropic receptors are involved in transmission of neurotransmitter. Io notropic receptors are transmembrane molecules that can open 07 close a channel that would allow smaller particles to travel in and out of the cell. As name implies, lonotropic receptors allow different kinds of lons to travel in and out of the cello They are generally closed, when a neurotransmitter - eligand) binds to the receptor, its confirmation changes and a small opening is created is big enough for ious to travel SE changet is big enou through . Metabotropic signaling & an this type of signaling metabotropic receptors are involved. in transmission of neurotransmitter. Metabotropic receptors do not have a channel that open are closes. Instead they are linked to another small Chemical called G- protein'. As soon as a ligand (Neurotransmitters binds to thes. receptors, ita activates the G-protein. once G-protein activated, it activates another molecule. This new molecule is called secondary messenger.

Similarities and differences : * Tonotropic and metabo tropic receptors are both ligand -gated trans membrane protein. Both involved in transmission of neurotransmitter. I onotropic bound by creates flow receptor change shape when they are a Ligand. This change in shape a channel that allows ious to through. Metabotropic receptors do not have channels. Metabotropic that in turn receptors activates activate a G-protein a secondary messenger. Io notropic receptors acts quickly while Metabotropic receptors takes a little longer depending on the number of steps required to produce a reaponse.

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